Tumor development and metastasis are facilitated by the complex interactions between
cancer cells and their microenvironment, which comprises stromal cells and extracellular …

Glioblastoma (GBM), the predominant and primary malignant intracranial tumor, poses a
formidable challenge due to its immunosuppressive microenvironment, thereby confounding …

Glioblastoma (GBM) is one of the most aggressive tumors in the adult central nervous
system. We previously revealed that circadian regulation of glioma stem cells (GSCs) affects …

Circadian rhythms are present in almost all cells and play a crucial role in regulating various
biological processes. Maintaining a stable circadian rhythm is essential for overall health …

Circadian timekee** mechanisms and cell cycle regulation share thematic biological
principles in responding to signals, repairing cellular damage, coordinating metabolism, and …

The symbiotic interactions between cancer stem cells and the tumor microenvironment
(TME) are critical for tumor progression. However, the molecular mechanism underlying this …

Simple Summary Initial clinical observations revealed strikingly longer follow-up for
metastatic non-small-cell lung cancer (NSCLC) patients receiving nivolumab infusions …

Tumor associated macrophages (TAMs) play an important role in tumorigenesis,
development and anti-cancer drug therapy. However, very few epigenetic compounds have …

Circadian rhythms of approximately 24 h have emerged as important modulators of the
immune system. These oscillations are important for mounting short-term, innate immune …

The circadian clock in animals and humans plays crucial roles in multiple physiological
processes. Disruption of circadian homeostasis causes detrimental effects. Here, it is …