Pancreatic cancer is a highly malignant digestive system tumor with a poor prognosis. Most
pancreatic cancer patients are diagnosed at an advanced stage or even metastasis due to …

Despite tremendous gains in the molecular understanding of exocrine pancreatic cancer,
the prognosis for this disease remains very poor, largely because of delayed disease …

This review aims to summarize the latest knowledge on factors, diagnosis, and treatment of
pancreatic cancer, and aims to promote further research on this under-studied malignant …

MicroRNAs (miRNAs) are short, noncoding, single-stranded RNA molecules that regulate
gene expression at the post-transcriptional level by binding to mRNAs. miRNAs affect the …

Most patients with pancreatic ductal adenocarcinoma (PDAC) present with symptomatic,
surgically unresectable disease. Although the goal of early detection of PDAC is laudable …

Abstract Background & Aims Pancreatic ductal adenocarcinoma (PDAC) incidence is rising
worldwide, and most patients present with an unresectable disease at initial diagnosis …

Fibrosis compromises pancreatic ductal carcinoma (PDAC) treatment and contributes to
patient mortality, yet antistromal therapies are controversial. We found that human PDACs …

Epidemiological studies demonstrate an association between breast cancer (BC) and
systemic dysregulation of glucose metabolism. However, how BC influences glucose …

With the emergence of genomic profiling technologies and selective molecular targeted
therapies, biomarkers play an increasingly important role in the clinical management of …

Early diagnosis of colon cancer (CC) is clinically important, as it can significantly improve
patients' survival rate and quality of life. Although the potential role for small extracellular …