Fibrinogen conversion into insoluble fibrin and the formation of a stable clot is the final step
of the coagulation cascade. Fibrin clot porosity and its susceptibility to plasmin-mediated …

Multiple mechanisms mediate thrombin generation and consequently the thrombin
concentration present during fibrin formation. First, the levels of pro-and anticoagulants …

Cardiovascular disease (CVD) is the leading cause of death and disability worldwide. The
primary prevention of CVD is dependent upon the ability to identify high-risk individuals long …

Thrombosis is a common disorder with a relevant burden of morbidity and mortality
worldwide, particularly among elderly patients. Growing evidence demonstrated a direct role …

Stroke is a leading cause of disability in adults that has a heavy social burden worldwide.
This disease is the third highest cause of mortality, resulting in approximately six million …

Objective: Post-translational modifications of fibrinogen influence the occurrence and
progression of thrombotic diseases. In this systematic review, we assessed the current …

Behçet's syndrome (BS) is a systemic vasculitis, clinically characterized by different organ
involvement and often complicated by thrombosis which occurs in vessels of all sizes …

Background—Behçet disease (BD) is a systemic vasculitis with a broad range of organ
involvement, characterized by a multisystemic, immune-inflammatory disorder involving …

Essentials• Patients with cirrhosis have hemostatic changes, which may contribute to a risk
of thrombosis.• This in vitro study compares clot formation and structure between patients …

Significance: Aging is a complex process associated with an increased risk of many
diseases, including thrombosis. This review summarizes age-related prothrombotic …