Cytochome c oxidase is the terminal member of the electron transport chains of
mitochondria and many bacteria. Providing an efficient mechanism for dioxygen reduction …

Electron-transfer reactions play essential roles in numerous important biological processes,
including photosynthesis, mitochondrial respiration, and intermediary metabolism. Kinetic …

Mixed quantum mechanical/molecular mechanics calculations were used to explore the
electron pathway of the terminal electron transfer enzyme, cytochrome c oxidase. This …

The spectral and kinetic characteristics of two oxidized states of bovine heart cytochrome c
oxidase (CcO) have been compared. The first is the oxidized state of enzyme isolated in the …

Bioelectronic coupling of multi-redox-site membrane proteins was accomplished with
cytochrome c oxidase (CcO) as an example. A biomimetic membrane system was used for …

Cytochrome-c oxidase is the terminal enzyme in the respiratory chains of mitochondria and
many bacteria and catalyzes the formation of water by reduction of dioxygen. The first step in …

Reoxidized cytochrome c oxidase appears to be in a 'high-energy'metastable state (OH) in
which part of the energy released in the redox reactions is stored. The OH is supposed to …

In aerobic organisms, cellular respiration is associated with electron transfer through a
respiratory system of membrane-bound complexes. This electron flow is terminated by the …

Time-resolved spectroscopic studies in our laboratory of bovine heart cytochrome c oxidase
dynamics are summarized. Intramolecular electron transfer was investigated upon …

The reduction of O2 in respiratory cytochrome c oxidases (CcO) is associated with the
generation of the transmembrane proton gradient by two mechanisms. In one of them, the …