Recent progress of SELEX methods for screening nucleic acid aptamers
C Zhu, Z Feng, H Qin, L Chen, M Yan, L Li, F Qu - Talanta, 2024 - Elsevier
Nucleic acid aptamers are oligonucleotide sequences screened by an in vitro methodology
called Systematic Evolution of Ligands by Exponential Enrichment (SELEX). Known as …
called Systematic Evolution of Ligands by Exponential Enrichment (SELEX). Known as …
Aptamers from random sequence space: Accomplishments, gaps and future considerations
Aptamers are molecular recognition elements made of nucleic acids. Diverse synthetic
aptamers have been discovered in a large number of SELEX experiments since 1990. This …
aptamers have been discovered in a large number of SELEX experiments since 1990. This …
Aptamer blocking strategy inhibits SARS‐CoV‐2 virus infection
M Sun, S Liu, X Wei, S Wan, M Huang… - Angewandte Chemie …, 2021 - Wiley Online Library
The COVID‐19 pandemic caused by SARS‐CoV‐2 is threating global health. Inhibiting
interaction of the receptor‐binding domain of SARS‐CoV‐2 S protein (SRBD) and human …
interaction of the receptor‐binding domain of SARS‐CoV‐2 S protein (SRBD) and human …
A colorimetric and photothermal dual-mode biosensing platform based on nanozyme-functionalized flower-like DNA structures for tumor-derived exosome detection
X Zhang, X Zhu, Y Li, X Hai, S Bi - Talanta, 2023 - Elsevier
Tumor-derived exosomes can be served as a kind of promising biomarkers for early
diagnosis of cancers. Herein, a colorimetric/photothermal dual-mode exosomes sensing …
diagnosis of cancers. Herein, a colorimetric/photothermal dual-mode exosomes sensing …
Asymmetrically split DNAzyme-based colorimetric and electrochemical dual-modal biosensor for detection of breast cancer exosomal surface proteins
W Cheng, Y Yao, D Li, C Duan, Z Wang… - Biosensors and …, 2023 - Elsevier
Exosomal surface proteins are potentially useful for breast cancer diagnosis and awareness
of risk. However, some detection techniques involving complex operations and expensive …
of risk. However, some detection techniques involving complex operations and expensive …
Effects of univariate stiffness and degradation of DNA hydrogels on the transcriptomics of neural progenitor cells
B Zhou, B Yang, Q Liu, L **, Y Shao… - Journal of the …, 2023 - ACS Publications
Mechanical interactions between cells and extracellular matrix (ECM) are critical for stem
cell fate decision. Synthetic models of ECM, such as hydrogels, can be used to precisely …
cell fate decision. Synthetic models of ECM, such as hydrogels, can be used to precisely …
Engineering a ligase binding DNA aptamer into a templating DNA scaffold to guide the selective synthesis of circular DNAzymes and DNA aptamers
Functional nucleic acids (FNAs), such as DNAzymes and DNA aptamers, can be engineered
into circular forms for improved performance. Circular FNAs are promising candidates for …
into circular forms for improved performance. Circular FNAs are promising candidates for …
Preparation, applications, and challenges of functional DNA nanomaterials
L Zhang, M Chu, C Ji, J Tan, Q Yuan - Nano Research, 2023 - Springer
As a carrier of genetic information, DNA is a versatile module for fabricating nanostructures
and nanodevices. Functional molecules could be integrated into DNA by precise base …
and nanodevices. Functional molecules could be integrated into DNA by precise base …
Evolution of a bispecific G-quadruplex-forming circular aptamer to block IL-6/sIL-6R interaction for inflammation inhibition
IL-6 (interleukin-6) is an essential cytokine that participates in many inflammatory and
immune responses, and disrupting the interaction between IL-6 and its receptor sIL-6R …
immune responses, and disrupting the interaction between IL-6 and its receptor sIL-6R …
Overview of the therapeutic potential of aptamers targeting coagulation factors
M Liu, K Zaman, YM Fortenberry - International Journal of Molecular …, 2021 - mdpi.com
Aptamers are single-stranded DNA or RNA sequences that bind target molecules with high
specificity and affinity. Aptamers exhibit several notable advantages over protein-based …
specificity and affinity. Aptamers exhibit several notable advantages over protein-based …