Copper(II) complexes as potential anticancer and Nonsteroidal anti-inflammatory agents: In vitro and in vivo studies

A Hussain, MF AlAjmi, MT Rehman, S Amir… - Scientific reports, 2019 - nature.com
Copper-based compounds are promising entities for target-specific next-generation
anticancer and NSAIDS therapeutics. In lieu of this, benzimidazole scaffold plays an …

Alpha-Amylase and Alpha-Glucosidase Enzyme Inhibition and Antioxidant Potential of 3-Oxolupenal and Katononic Acid Isolated from Nuxia oppositifolia

AS Alqahtani, S Hidayathulla, MT Rehman… - Biomolecules, 2019 - mdpi.com
Nuxia oppositifolia is traditionally used in diabetes treatment in many Arabian countries;
however, scientific evidence is lacking. Hence, the present study explored the antidiabetic …

Anti-oxidant and anti-inflammatory effects of cinnamaldehyde and eugenol on mononuclear cells of rheumatoid arthritis patients

S Mateen, MT Rehman, S Shahzad, SS Naeem… - European journal of …, 2019 - Elsevier
Rheumatoid arthritis (RA) is an autoimmune disorder affecting joints and frequently
characterized by initial local and later systemic inflammation. The present study was …

Molecular insight into binding behavior of polyphenol (rutin) with beta lactoglobulin: Spectroscopic, molecular docking and MD simulation studies

NA Al-Shabib, JM Khan, A Malik, MA Alsenaidy… - Journal of Molecular …, 2018 - Elsevier
The interaction of natural polyphenolic compounds (rutin) with β-lactoglobulin (BLG) was
carried out by using several optical spectroscopic (UV–visible spectroscopy, fluorescence …

Natural compounds as inhibitors of SARS-CoV-2 main protease (3CLpro): A molecular docking and simulation approach to combat COVID-19

MT Rehman, MF AlAjmi… - Current pharmaceutical …, 2021 - benthamdirect.com
Background: The emergence and dissemination of SARS-CoV-2 has caused high mortality
and enormous economic loss. Rapid development of new drug molecules is the need of …

[HTML][HTML] Plant-derived antiviral drugs as novel hepatitis B virus inhibitors: Cell culture and molecular docking study

MK Parvez, MT Rehman, P Alam, MS Al-Dosari… - Saudi Pharmaceutical …, 2019 - Elsevier
Despite high anti-HBV efficacies, while the nucleoside analogs (eg, lamivudine) lead to the
emergence of drug-resistance, interferons (eg, IFN-α causes adverse side-effects …

Molecular hybrids based on 1, 2, 3-triazole and 1, 3, 4-thiadiazole cores: Synthesis, characterization, anticancer activity and in silico study

A Oubella, A Bimoussa, MT Rehman, MF AlAjmi… - Journal of Molecular …, 2024 - Elsevier
Abstract One sets of 1, 3, 4-thiadiazole analogs 14a-c and 15a-c were synthesized by the
incorporation of two heterocyclic nuclei (1, 2, 3-triazole & 1, 3, 4-thiadiazoles) in objective of …

Pharmacoinformatics approach for the identification of Polo-like kinase-1 inhibitors from natural sources as anti-cancer agents

MF AlAjmi, MT Rehman, A Hussain… - International journal of …, 2018 - Elsevier
Abstract Polo-like kinase-1 (PLK-1) plays a key role in cell cycle progression during mitosis.
Overexpression/dysfunction of PLK-1 is directly associated with cancerous transformation …

Targeted synthesis via the structure-activity relationship: Biological evaluation of new 1, 2, 3-triazoles monoterpene as antitumor agents

E Irrou, YA Elmachkouri, S El Haddad, Y Riadi… - Journal of Molecular …, 2024 - Elsevier
A novel series of thiazolidinone based 1, 2, 3-triazole derivatives were designed,
synthesized, and evaluated for their cytotoxic activity against four human cancer cell lines …

Understanding Antibiotic Detection with Fluorescence Quantum Dots: A Review

S Sudewi, PV Sai Sashank, R Kamaraj, M Zulfajri… - Journal of …, 2024 - Springer
The utilization of fluorescent quantum dots (FL QDs) has gained significant traction in the
realm of antibiotic detection, owing to their exceptional FL properties and versatility. Various …