Progress and challenges of immunotherapy in triple-negative breast cancer

Y Zhu, X Zhu, C Tang, X Guan, W Zhang - Biochimica et Biophysica Acta …, 2021 - Elsevier
Triple-negative breast cancer (TNBC), a subtype of breast cancer, is defined as lacking
estrogen receptor (ER), progesterone receptor (PR), and human epidermal growth factor …

An update on treatment options for pancreatic adenocarcinoma

A Lambert, L Schwarz, I Borbath… - … in medical oncology, 2019 - journals.sagepub.com
Pancreatic cancer is one of the most lethal solid organ tumors. Due to the rising incidence,
late diagnosis, and limited treatment options, it is expected to be the second leading cause …

Pancreatic cancer and immunotherapy: a clinical overview

FEF Timmer, B Geboers, S Nieuwenhuizen, M Dijkstra… - Cancers, 2021 - mdpi.com
Simple Summary Pancreatic ductal adenocarcinoma (PDAC) is an aggressive cancer with a
dismal prognosis. While immunotherapy has been deemed a breakthrough treatment for …

Cell-penetrating peptides enhance peptide vaccine accumulation and persistence in lymph nodes to drive immunogenicity

CM Backlund, RL Holden… - Proceedings of the …, 2022 - National Acad Sciences
Peptide-based cancer vaccines are widely investigated in the clinic but exhibit modest
immunogenicity. One approach that has been explored to enhance peptide vaccine potency …

[HTML][HTML] Systemic treatment of pancreatic cancer revisited

M Ducreux, T Seufferlein, JL Van Laethem… - Seminars in …, 2019 - Elsevier
Pancreatic cancer is considered to be one of the most aggressive cancers. For unknown
reasons, the incidence of pancreatic cancer is slowly rising and so too are mortality rates …

[HTML][HTML] Perspectives in the treatment of pancreatic adenocarcinoma

A Cid-Arregui, V Juarez - World journal of gastroenterology: WJG, 2015 - ncbi.nlm.nih.gov
Pancreatic ductal adenocarcinoma (PDAC) is an incurable lethal disease whose incidence
rate is growing. There is no effective screening for detection of early stage tumors and, in …

Therapeutic cancer vaccines: From initial findings to prospects

Q Song, C Zhang, X Wu - Immunology letters, 2018 - Elsevier
With the approval of the first therapeutic cancer vaccine by US Food and Drug
Administration, numerous therapeutic cancer vaccines have been under clinical trials with …

[HTML][HTML] Immunotherapy in pancreatic ductal adenocarcinoma: an emerging entity?

IH Sahin, G Askan, ZI Hu, EM O'Reilly - Annals of Oncology, 2017 - Elsevier
The genomic-plasticity of the immune system creates a broad immune repertoire engaged to
tackle cancer cells. Promising clinical activity has been observed with several immune …

Trial Watch: Peptide-based anticancer vaccines

J Pol, N Bloy, A Buqué, A Eggermont, I Cremer… - …, 2015 - Taylor & Francis
Malignant cells express antigens that can be harnessed to elicit anticancer immune
responses. One approach to achieve such goal consists in the administration of tumor …

The clinical terrain of immunotherapies in heterogeneous pancreatic cancer: Unravelling challenges and opportunities

M Herpels, J Ishihara… - The Journal of …, 2023 - Wiley Online Library
Pancreatic ductal adenocarcinoma (PDAC) is the most common and aggressive type of
pancreatic cancer and has abysmal survival rates. In the past two decades …