Mitral valve disease—morphology and mechanisms

RA Levine, AA Hagége, DP Judge, M Padala… - Nature reviews …, 2015‏ - nature.com
Mitral valve disease is a frequent cause of heart failure and death. Emerging evidence
indicates that the mitral valve is not a passive structure, but—even in adult life—remains …

Contemporary insights into the functional anatomy of the mitral valve

JJ Silbiger, R Bazaz - American heart journal, 2009‏ - Elsevier
The mitral valve is a highly complex structure the normal functioning of which requires the
coordinated interaction of the leaflets, annulus, chordae tendineae, and papillary muscles …

Frontiers in growth and remodeling

A Menzel, E Kuhl - Mechanics research communications, 2012‏ - Elsevier
Unlike common engineering materials, living matter can autonomously respond to
environmental changes. Living structures can grow stronger, weaker, larger, or smaller …

Computational modeling of passive myocardium

S Göktepe, SNS Acharya, J Wong… - International Journal for …, 2011‏ - Wiley Online Library
This work deals with the computational modeling of passive myocardial tissue within the
framework of mixed, non‐linear finite element methods. We consider a recently proposed …

Computational modeling of cardiac valve function and intervention

W Sun, C Martin, T Pham - Annual review of biomedical …, 2014‏ - annualreviews.org
In the past two decades, major advances have been made in the clinical evaluation and
treatment of valvular heart disease owing to the advent of noninvasive cardiac imaging …

On the effect of prestrain and residual stress in thin biological membranes

MK Rausch, E Kuhl - Journal of the Mechanics and Physics of Solids, 2013‏ - Elsevier
Understanding the difference between ex vivo and in vivo measurements is critical to
interpret the load carrying mechanisms of living biological systems. For the past four …

Computational modeling of growth: systemic and pulmonary hypertension in the heart

MK Rausch, A Dam, S Göktepe, OJ Abilez… - … and modeling in …, 2011‏ - Springer
We introduce a novel constitutive model for growing soft biological tissue and study its
performance in two characteristic cases of mechanically induced wall thickening of the heart …

On the In Vivo Deformation of the Mitral Valve Anterior Leaflet: Effects of Annular Geometry and Referential Configuration

R Amini, CE Eckert, K Koomalsingh… - Annals of biomedical …, 2012‏ - Springer
Alteration of the native mitral valve (MV) shape has been hypothesized to have a profound
effect on the local tissue stress distribution, and is potentially linked to limitations in repair …

Mechanics of the mitral valve: a critical review, an in vivo parameter identification, and the effect of prestrain

MK Rausch, N Famaey, TOB Shultz, W Bothe… - … and modeling in …, 2013‏ - Springer
Alterations in mitral valve mechanics are classical indicators of valvular heart disease, such
as mitral valve prolapse, mitral regurgitation, and mitral stenosis. Computational modeling is …

A fully implicit finite element method for bidomain models of cardiac electromechanics

H Dal, S Göktepe, M Kaliske, E Kuhl - Computer methods in applied …, 2013‏ - Elsevier
We propose a novel, monolithic, and unconditionally stable finite element algorithm for the
bidomain-based approach to cardiac electromechanics. We introduce the transmembrane …