ATP-binding cassette (ABC) transporters mediate the ATP-driven translocation of structurally
and mechanistically distinct substrates against steep concentration gradients. Among the …

The ATP‐binding cassette (ABC) transporter superfamily is one of the largest membrane
protein families existing in wide spectrum of organisms from prokaryotes to human. ABC …

Background Although gemcitabine has been considered as the first-line drug for advanced
pancreatic cancer (PC), development of resistance to gemcitabine severely limits the …

The ATP-binding cassette transporter G2 (ABCG2; also known as breast cancer resistance
protein, BCRP) has been suggested to be involved in clinical multidrug resistance (MDR) in …

FAK is a nonreceptor intracellular tyrosine kinase which plays an important biological
function. Many studies have found that FAK is overexpressed in many human cancer cell …

Focal adhesion kinase (FAK), a non-receptor tyrosine kinase, plays an essential role in
regulating cell proliferation, migration and invasion through both kinase-dependent …

Focal adhesion kinase (FAK, also known as PTK2) is a tyrosine kinase that regulates
integrin and growth factor signaling pathways and is involved in the migration, proliferation …

Focal adhesion kinase (FAK) is a nonreceptor intracellular tyrosine kinase that plays an
essential role in cancer cell adhesion, survival, proliferation, and migration through both its …

Triple-negative breast cancer (TNBC) is an aggressive breast tumor subtype that currently
lacks targeted treatment options. The role played by the insulin-like growth factor-1 (IGF-1) …

Introduction: Focal adhesion kinase (FAK) is a promising target for the treatment of solid
tumors because its expression has been linked to tumor progression, invasion, and drug …