Prior mouse genetic research has set the stage for a deep understanding of appetite
regulation. This goal is now being realized through the use of recent technological …

During the past 30 yr, investigating the physiology of eating behaviors has generated a truly
vast literature. This is fueled in part by a dramatic increase in obesity and its comorbidities …

Obesity represents the single most important risk factor for early disability and death in
developed societies, and the incidence of obesity remains at staggering levels. CNS …

The initial discovery that ob/ob mice become obese because of a recessive mutation of the
leptin gene has been crucial to discover the melanocortin pathway to control appetite. In the …

Among the most widely used animal models in obesity-induced type 2 diabetes mellitus
(T2DM) research are the congenital leptin-and leptin receptor-deficient rodent models …

A strong grounding in basic histology is essential for all pathologists. However, there had
always been a gap between histology and pathology in which histologic information …

New information regarding neuronal circuits that control food intake and their hormonal
regulation has extended our understanding of energy homeostasis, the process whereby …

Leptin is secreted into the bloodstream by adipocytes and is required for the maintenance of
energy homeostasis and body weight. Leptin deficiency or genetic defects in the …

The focus of this overview is on the animal models of obesity most commonly utilized in
research. The models include monogenic models in the leptin pathway, polygenic diet …

Abstract The melanocortin-4 receptor (MC4-R) is a G protein–coupled, seven-
transmembrane receptor expressed in the brain. Inactivation of this receptor by gene …