Hydroxytyrosol, tyrosol and derivatives and their potential effects on human health

A Karković Marković, J Torić, M Barbarić… - Molecules, 2019 - mdpi.com
The Mediterranean diet and olive oil as its quintessential part are almost synonymous with a
healthy way of eating and living nowadays. This kind of diet has been highly appreciated …

Polyphenols from food and natural products: Neuroprotection and safety

RFM Silva, L Pogačnik - Antioxidants, 2020 - mdpi.com
Polyphenols are naturally occurring micronutrients that are present in many food sources.
Besides being potent antioxidants, these molecules may also possess anti-inflammatory …

Causative links between protein aggregation and oxidative stress: a review

E Lévy, N El Banna, D Baïlle… - International journal of …, 2019 - mdpi.com
Compelling evidence supports a tight link between oxidative stress and protein aggregation
processes, which are noticeably involved in the development of proteinopathies, such as …

Oleuropein, a Bioactive Compound from Olea europaea L., as a Potential Preventive and Therapeutic Agent in Non-Communicable Diseases

C Nediani, J Ruzzolini, A Romani, L Calorini - Antioxidants, 2019 - mdpi.com
Growing scientific literature data suggest that the intake of natural bioactive compounds
plays a critical role in preventing or reducing the occurrence of human chronic non …

Targeting amyloid aggregation: an overview of strategies and mechanisms

S Giorgetti, C Greco, P Tortora, FA Aprile - International journal of …, 2018 - mdpi.com
Amyloids result from the aggregation of a set of diverse proteins, due to either specific
mutations or promoting intra-or extra-cellular conditions. Structurally, they are rich in …

Inhibition of protein misfolding and aggregation by natural phenolic compounds

Z Dhouafli, K Cuanalo-Contreras, EA Hayouni… - Cellular and molecular …, 2018 - Springer
Protein misfolding and aggregation into fibrillar deposits is a common feature of a large
group of degenerative diseases affecting the central nervous system or peripheral organs …

Healthspan Maintenance and Prevention of Parkinson's-like Phenotypes with Hydroxytyrosol and Oleuropein Aglycone in C. elegans

G Brunetti, G Di Rosa, M Scuto, M Leri… - International journal of …, 2020 - mdpi.com
Numerous studies highlighted the beneficial effects of the Mediterranean diet (MD) in
maintaining health, especially during ageing. Even neurodegeneration, which is part of the …

Neuroprotective and symptomatic effects of cannabidiol in an animal model of Parkinson's disease

C Giuliano, M Francavilla, G Ongari, A Petese… - International Journal of …, 2021 - mdpi.com
Parkinson's disease (PD) is a neurodegenerative disorder characterized by the loss of
dopaminergic neurons in the Substantia Nigra pars compacta, leading to classical PD motor …

Dietary antioxidants and Parkinson's disease

HA Park, AC Ellis - Antioxidants, 2020 - mdpi.com
Parkinson's disease (PD) is a neurodegenerative disorder caused by the depletion of
dopaminergic neurons in the basal ganglia, the movement center of the brain …

Potential role of natural polyphenols against protein aggregation toxicity: in vitro, in vivo, and clinical studies

G Henríquez, A Gomez, E Guerrero… - ACS Chemical …, 2020 - ACS Publications
One of the main features of neurodegenerative disorders such as Alzheimer's disease and
Parkinson's disease is the amyloidogenic behavior of disease-specific proteins including …