Avidity in antibody effector functions and biotherapeutic drug design
SC Oostindie, GA Lazar, J Schuurman… - Nature Reviews Drug …, 2022 - nature.com
Antibodies are the cardinal effector molecules of the immune system and are being
leveraged with enormous success as biotherapeutic drugs. A key part of the adaptive …
leveraged with enormous success as biotherapeutic drugs. A key part of the adaptive …
High-resolution native mass spectrometry
Native mass spectrometry (MS) involves the analysis and characterization of
macromolecules, predominantly intact proteins and protein complexes, whereby as much as …
macromolecules, predominantly intact proteins and protein complexes, whereby as much as …
Tip** the balance: intricate roles of the complement system in disease and therapy
The ability of the complement system to rapidly and broadly react to microbial intruders,
apoptotic cells and other threats by inducing forceful elimination responses is indispensable …
apoptotic cells and other threats by inducing forceful elimination responses is indispensable …
Complement in neurological disorders and emerging complement-targeted therapeutics
The complement system consists of a network of plasma and membrane proteins that
modulate tissue homeostasis and contribute to immune surveillance by interacting with the …
modulate tissue homeostasis and contribute to immune surveillance by interacting with the …
[HTML][HTML] Structure, function, and therapeutic use of IgM antibodies
Natural immunoglobulin M (IgM) antibodies are pentameric or hexameric macro-
immunoglobulins and have been highly conserved during evolution. IgMs are initially …
immunoglobulins and have been highly conserved during evolution. IgMs are initially …
Amine headgroups in ionizable lipids drive immune responses to lipid nanoparticles by binding to the receptors TLR4 and CD1d
Lipid nanoparticles (LNPs) are the most clinically advanced delivery vehicle for RNA
therapeutics, partly because of established lipid structure–activity relationships focused on …
therapeutics, partly because of established lipid structure–activity relationships focused on …
The development and consequences of red blood cell alloimmunization
While red blood cell (RBC) transfusion is the most common medical intervention in
hospitalized patients, as with any therapeutic, it is not without risk. Allogeneic RBC exposure …
hospitalized patients, as with any therapeutic, it is not without risk. Allogeneic RBC exposure …
Complement is activated by elevated IgG3 hexameric platforms and deposits C4b onto distinct antibody domains
IgG3 is unique among the IgG subclasses due to its extended hinge, allotypic diversity and
enhanced effector functions, including highly efficient pathogen neutralisation and …
enhanced effector functions, including highly efficient pathogen neutralisation and …
IgG hexamers initiate complement-dependent acute lung injury
Antibodies can initiate lung injury in a variety of disease states such as autoimmunity, in
reactions to transfusions, or after organ transplantation, but the key factors determining in …
reactions to transfusions, or after organ transplantation, but the key factors determining in …
Role of polymeric immunoglobulin receptor in IgA and IgM transcytosis
H Wei, JY Wang - International Journal of Molecular Sciences, 2021 - mdpi.com
Transcytosis of polymeric IgA and IgM from the basolateral surface to the apical side of the
epithelium and subsequent secretion into mucosal fluids are mediated by the polymeric …
epithelium and subsequent secretion into mucosal fluids are mediated by the polymeric …