Zinc is essential to all forms of life, 1-4 with an average adult human containing ca. 3 g of
zinc. 5 For example, zinc is indispensable for effective growth and development, has …

The manipulation of phosphate ester linkages is very important in the chemistry of life. Cells
possess highly evolved enzymatic machinery to make and break these linkages, which are …

The development of synthetic agents able to hydrolytically cleave DNA with high efficiency
and selectivity is still a fascinating challenge. Over the years, many examples have been …

Here we show that a recent computationally designed zinc-mediated protein interface is
serendipitously capable of catalyzing carboxyester and phosphoester hydrolysis. Although …

Phosphate Diester and DNA Hydrolysis by a Multivalent, Nanoparticle-Based Catalyst |
Journal of the American Chemical Society Recently Viewedclose modal ACS ACS …

" Designing artificial systems with catalytic efficiencies to rival those of natural enzymes is
one of the great challenges facing science today. Our current level of understanding fails the …

The development of synthetic agents able to hydrolytically cleave phosphate diester bonds
with high efficiency is a fascinating challenge, which will ultimately open the way to artificial …

A series of cis-cis-triaminocyclohexane Zn (II) complex− anthraquinone intercalator
conjugates, designed in such a way to allow their easy synthesis and modification, have …

A series of pyrazolate-based dizinc (II) complexes has been synthesized and investigated as
functional models for phosphoesterases, focusing on correlations between hydrolytic activity …

Hydrolysis of 4-nitrophenyl phosphate (NPP) and bis-4-nitrophenyl phosphate (BNPP), two
commonly used DNA model substrates, was examined in vanadate solutions by means of …