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Environmental toxicity, oxidative stress and apoptosis: menage a trois
Apoptosis is an evolutionary conserved homeostatic process involved in distinct
physiological processes including organ and tissue morphogenesis, development and …
physiological processes including organ and tissue morphogenesis, development and …
Telomere length is a biomarker of cumulative oxidative stress, biologic age, and an independent predictor of survival and therapeutic treatment requirement …
MA Babizhayev, EL Savel'yeva… - American journal of …, 2011 - journals.lww.com
Globally, tobacco use is associated with 5 million deaths per annum and is regarded as one
of the leading causes of premature death. Major chronic disorders associated with smoking …
of the leading causes of premature death. Major chronic disorders associated with smoking …
Vapors produced by electronic cigarettes and e-juices with flavorings induce toxicity, oxidative stress, and inflammatory response in lung epithelial cells and in mouse …
Oxidative stress and inflammatory response are the key events in the pathogenesis of
chronic airway diseases. The consumption of electronic cigarettes (e-cigs) with a variety of e …
chronic airway diseases. The consumption of electronic cigarettes (e-cigs) with a variety of e …
Cytotoxicity evaluation of electronic cigarette vapor extract on cultured mammalian fibroblasts (ClearStream-LIFE): comparison with tobacco cigarette smoke extract
G Romagna, E Allifranchini, E Bocchietto… - Inhalation …, 2013 - Taylor & Francis
Abstract Context: Electronic cigarettes (ECs) are used as alternatives to smoking; however,
data on their cytotoxic potential are scarce. Objective: To evaluate the cytotoxic potential of …
data on their cytotoxic potential are scarce. Objective: To evaluate the cytotoxic potential of …
Oxidative stress induces persistent telomeric DNA damage responsible for nuclear morphology change in mammalian cells
E Coluzzi, M Colamartino, R Cozzi, S Leone… - PloS one, 2014 - journals.plos.org
One main function of telomeres is to maintain chromosome and genome stability. The rate of
telomere shortening can be accelerated significantly by chemical and physical …
telomere shortening can be accelerated significantly by chemical and physical …
Cigarette smoke-induced mitochondrial fragmentation and dysfunction in human airway smooth muscle
B Aravamudan, A Kiel, M Freeman… - … of Physiology-Lung …, 2014 - journals.physiology.org
The balance between mitochondrial fission and fusion is crucial for mitochondria to perform
its normal cellular functions. We hypothesized that cigarette smoke (CS) disrupts this …
its normal cellular functions. We hypothesized that cigarette smoke (CS) disrupts this …
Tobacco smoke induces the generation of procoagulant microvesicles from human monocytes/macrophages
Objective—To investigate whether exposure of human monocytes/macrophages to tobacco
smoke induces their release of membrane microvesicles (MVs) that carry tissue factor (TF) …
smoke induces their release of membrane microvesicles (MVs) that carry tissue factor (TF) …
The Aryl Hydrocarbon Receptor Attenuates Tobacco Smoke-induced Cyclooxygenase-2 and Prostaglandin Production in Lung Fibroblasts through Regulation of the …
CJ Baglole, SB Maggirwar, TA Gasiewicz… - Journal of Biological …, 2008 - jbc.org
Diseases such as chronic obstructive pulmonary disease and lung cancer caused by
cigarette smoke affect millions of people worldwide. The aryl hydrocarbon receptor (AhR) is …
cigarette smoke affect millions of people worldwide. The aryl hydrocarbon receptor (AhR) is …
[HTML][HTML] Novel proteolytic microvesicles released from human macrophages after exposure to tobacco smoke
CJ Li, Y Liu, Y Chen, D Yu, KJ Williams… - The American journal of …, 2013 - Elsevier
Cigarette smoking damages the extracellular matrix in a variety of locations, leading to
atherosclerotic plaque instability and emphysematous lung destruction, but the underlying …
atherosclerotic plaque instability and emphysematous lung destruction, but the underlying …
Molecular regulation of cigarette smoke induced-oxidative stress in human retinal pigment epithelial cells: implications for age-related macular degeneration
KM Bertram, CJ Baglole, RP Phipps… - American Journal of …, 2009 - journals.physiology.org
Cigarette smoke is the most important environmental risk factor for develo** age-related
macular degeneration (AMD). Damage to the retinal pigment epithelium (RPE) caused by …
macular degeneration (AMD). Damage to the retinal pigment epithelium (RPE) caused by …