Role of Fc core fucosylation in the effector function of IgG1 antibodies
The presence of fucose on IgG1 Asn-297 N-linked glycan is the modification of the human
IgG1 Fc structure with the most significant impact on FcɣRIII affinity. It also significantly …
IgG1 Fc structure with the most significant impact on FcɣRIII affinity. It also significantly …
Glycosylation of immunoglobin G in tumors: Function, regulation and clinical implications
Immunoglobulin G (IgG) is the predominant component in humoral immunity and the major
effector of neutralizing heterogeneous antigens. Glycosylation, as excessive …
effector of neutralizing heterogeneous antigens. Glycosylation, as excessive …
Flux balance analysis and peptide map** elucidate the impact of bioreactor pH on Chinese hamster ovary (CHO) cell metabolism and N-linked glycosylation in the …
Culture conditions have a profound impact on therapeutic protein production and
glycosylation, a critical therapeutic-quality attribute, especially for monoclonal antibodies …
glycosylation, a critical therapeutic-quality attribute, especially for monoclonal antibodies …
Engineering nucleotide sugar synthesis pathways for independent and simultaneous modulation of N-glycan galactosylation and fucosylation in CHO cells
Glycosylation of recombinant therapeutics like monoclonal antibodies (mAbs) is a critical
quality attribute. N-glycans in mAbs are known to affect various effector functions, and …
quality attribute. N-glycans in mAbs are known to affect various effector functions, and …
[PDF][PDF] An engineered immunomodulatory IgG1 Fc suppresses autoimmune inflammation through pathways shared with iv immunoglobulin
Immunoglobulin G (IgG) antibodies in the form of high-dose intravenous immunoglobulin
(IVIG) exert immunomodulatory activity and are used in this capacity to treat inflammatory …
(IVIG) exert immunomodulatory activity and are used in this capacity to treat inflammatory …
[HTML][HTML] Biomanufacturing of glycosylated antibodies: Challenges, solutions, and future prospects
Traditionally, recombinant protein production has been done in several expression hosts of
bacteria, fungi, and majorly CHO (Chinese Hamster Ovary) cells; few have high production …
bacteria, fungi, and majorly CHO (Chinese Hamster Ovary) cells; few have high production …
A Novel, Site‐Specific N‐Linked Glycosylation Model Provides Mechanistic Insights Into the Process‐Condition Dependent Distinct Fab and Fc Glycosylation of an …
The CHO VRC01 cell line produces an anti‐HIV IgG1 monoclonal antibody containing N‐
linked glycans on both the Fab (variable) and Fc (constant) regions. Site‐specific glycan …
linked glycans on both the Fab (variable) and Fc (constant) regions. Site‐specific glycan …
Recent advances in antibody glycoengineering for the gain of functions
Z Liu, X Zou, F Tang, W Huang - Current Opinion in Chemical Biology, 2024 - Elsevier
Glycans play important roles in antibody functions, and antibody glycoengineering has long
been an important research field. Here, we summarize the significant strategies of antibody …
been an important research field. Here, we summarize the significant strategies of antibody …
[HTML][HTML] Combination of sodium butyrate and decitabine promotes transgene expression in CHO cells via apoptosis inhibition
W Li, Z Fan, X Wang, Y Lin, TY Wang - New Biotechnology, 2022 - Elsevier
Chinese hamster ovary (CHO) cells are currently the most widely used host cells for
production of recombinant therapeutic proteins (RTPs). Small-molecule additives related to …
production of recombinant therapeutic proteins (RTPs). Small-molecule additives related to …
Comprehensive N-and O-glycoproteomic analysis of multiple Chinese hamster ovary host cell lines
Glycoproteomic analysis of three Chinese hamster ovary (CHO) suspension host cell lines
(CHO-K1, CHO-S, and CHO-Pro5) commonly utilized in biopharmaceutical settings for …
(CHO-K1, CHO-S, and CHO-Pro5) commonly utilized in biopharmaceutical settings for …