The extracellular matrix (ECM) is the complex meshwork of proteins and glycans that forms
the scaffold that surrounds and supports cells. It exerts key roles in all aspects of metazoan …

The traditional two-dimensional (2D) in vitro cell culture system (on a flat support) has long
been used in cancer research. However, this system cannot be fully translated into clinical …

The dynamic interactions of cancer cells with their microenvironment consisting of stromal
cells (cellular part) and extracellular matrix (ECM) components (non-cellular) is essential to …

Biomolecular and physical cues of the extracellular matrix environment regulate collective
cell dynamics and tissue patterning. Nonetheless, how the viscoelastic properties of the …

The tumor microenvironment is proposed to contribute substantially to the progression of
cancers, including breast cancer. Cancer‐associated fibroblasts (CAFs) are the most …

Metastasis is the primary cause of cancer morbidity and mortality. The process involves a
complex interplay between intrinsic tumor cell properties as well as interactions between …

The mechanics of the cellular microenvironment continuously modulates cell functions such
as growth, survival, apoptosis, differentiation and morphogenesis via cytoskeletal …

The mechanical properties of cells and tissues help determine their architecture,
composition and function. Alterations to these properties are associated with many diseases …

The field of Brillouin microscopy and imaging was established approximately 20 years ago,
thanks to the development of non-scanning high-resolution optical spectrometers. Since …

YAP is a mechanosensitive transcriptional activator with a critical role in cancer,
regeneration, and organ size control. Here, we show that force applied to the nucleus …