Mechanisms of HBV-induced hepatocellular carcinoma

M Levrero, J Zucman-Rossi - Journal of hepatology, 2016 - Elsevier
Hepatitis B virus (HBV) contributes to hepatocellular carcinoma (HCC) development through
direct and indirect mechanisms. HBV DNA integration into the host genome occurs at early …

HBV DNA integration: molecular mechanisms and clinical implications

T Tu, MA Budzinska, NA Shackel, S Urban - Viruses, 2017 - mdpi.com
Chronic infection with the Hepatitis B Virus (HBV) is a major cause of liver-related morbidity
and mortality. One peculiar observation in cells infected with HBV (or with closely‑related …

[HTML][HTML] Hepatitis B viral protein HBx and the molecular mechanisms modulating the hallmarks of hepatocellular carcinoma: a comprehensive review

E Sivasudhan, N Blake, Z Lu, J Meng, R Rong - Cells, 2022 - mdpi.com
With 296 million cases estimated worldwide, chronic hepatitis B virus (HBV) infection is the
most common risk factor for hepatocellular carcinoma (HCC). HBV-encoded oncogene X …

Genomic medicine and implications for hepatocellular carcinoma prevention and therapy

R Dhanasekaran, JC Nault, LR Roberts… - Gastroenterology, 2019 - Elsevier
The pathogenesis of hepatocellular carcinoma (HCC) is poorly understood, but recent
advances in genomics have increased our understanding of the mechanisms by which …

Hepatitis B virus genotypes and variants

CL Lin, JH Kao - Cold Spring Harbor …, 2015 - perspectivesinmedicine.cshlp.org
At least 10 hepatitis B virus (HBV) genotypes (A to J) with distinct geographic distributions
and several HBV mutants, including precore/core promoter mutations and pre-S/S deletion …

Natural history of acute and chronic hepatitis B: the role of HBV genotypes and mutants

CL Lin, JH Kao - Best Practice & Research Clinical Gastroenterology, 2017 - Elsevier
Molecular epidemiologic studies reveal remarkable differences in the geographical
distribution of hepatitis B virus (HBV) genotypes. The frequency of mutants among HBV …

Effect of antiviral treatment with nucleotide/nucleoside analogs on postoperative prognosis of hepatitis B virus–related hepatocellular carcinoma: a two-stage …

J Yin, N Li, Y Han, J Xue, Y Deng, J Shi… - Journal of clinical …, 2013 - ascopubs.org
Purpose Postoperative prognosis of hepatitis B virus (HBV)–related hepatocellular
carcinoma (HCC) is poor. The effect of nucleotide/nucleoside analog (NA) treatment on the …

Pathogenicity and virulence of Hepatitis B virus

YC Chuang, KN Tsai, JHJ Ou - Virulence, 2022 - Taylor & Francis
Hepatitis B virus (HBV) is a hepatotropic virus and an important human pathogen. There are
an estimated 296 million people in the world that are chronically infected by this virus, and …

HBV-integration studies in the clinic: role in the natural history of infection

T Pollicino, G Caminiti - Viruses, 2021 - mdpi.com
Hepatitis B virus (HBV) infection is a major global health problem causing acute and chronic
liver disease that can lead to liver cirrhosis and hepatocellular carcinoma (HCC). HBV …

Hepatitis B virus x protein in the pathogenesis of hepatitis B virus‐induced hepatocellular carcinoma

MC Kew - Journal of gastroenterology and hepatology, 2011 - Wiley Online Library
Currently available evidence supports a role for the hepatitis B virus (HBV) x gene and
protein in the pathogenesis of HBV‐induced hepatocellular carcinoma (HCC). HBx gene is …