11β-hydroxysteroid dehydrogenases: intracellular gate-keepers of tissue glucocorticoid action

K Chapman, M Holmes, J Seckl - Physiological reviews, 2013 - journals.physiology.org
Glucocorticoid action on target tissues is determined by the density of “nuclear” receptors
and intracellular metabolism by the two isozymes of 11β-hydroxysteroid dehydrogenase …

Plastics derived endocrine‐disrupting compounds and their effects on early development

S Basak, MK Das, AK Duttaroy - Birth defects research, 2020 - Wiley Online Library
Despite the fact that the estrogenic effects of bisphenols were first described 80 years ago,
recent data about its potential negative impact on birth outcome parameters raises a strong …

Prenatal stress and epigenetics

L Cao-Lei, SR De Rooij, S King, SG Matthews… - Neuroscience & …, 2020 - Elsevier
In utero exposure to environmental stress in both animals and humans could result in long-
term epigenome alterations which further lead to consequences for adaptation and …

Prenatal stress, glucocorticoids and the programming of adult disease

EC Cottrell, J Seckl - Frontiers in behavioral neuroscience, 2009 - frontiersin.org
Numerous clinical studies associate an adverse prenatal environment with the development
of cardio-metabolic disorders and neuroendocrine dysfunction, as well as an increased risk …

Mechanisms of disease: glucocorticoids, their placental metabolism and fetal'programming'of adult pathophysiology

JR Seckl, MC Holmes - Nature clinical practice Endocrinology & …, 2007 - nature.com
Epidemiological evidence suggests that an adverse prenatal environment
permanently'programs' physiology and increases the risk of cardiovascular, metabolic …

Maternal psychosocial stress during pregnancy alters the epigenetic signature of the glucocorticoid receptor gene promoter in their offspring: a meta-analysis

H Palma-Gudiel, A Córdova-Palomera, E Eixarch… - Epigenetics, 2015 - Taylor & Francis
Prenatal stress has been widely associated with a number of short-and long-term
pathological outcomes. Epigenetic mechanisms are thought to partially mediate these …

Prenatal glucocorticoids and long-term programming

JR Seckl - European journal of endocrinology, 2004 - academic.oup.com
Epidemiological evidence suggests that low birth weight is associated with an increased risk
of cardiovascular, metabolic and neuroendocrine disorders in adult life. Glucocorticoid …

Endocrine regulation of human fetal growth: the role of the mother, placenta, and fetus

VE Murphy, R Smith, WB Giles, VL Clifton - Endocrine reviews, 2006 - academic.oup.com
The environment in which the fetus develops is critical for its survival and long-term health.
The regulation of normal human fetal growth involves many multidirectional interactions …

Epigenetic mechanisms of perinatal programming of hypothalamic-pituitary-adrenal function and health

MJ Meaney, M Szyf, JR Seckl - Trends in molecular medicine, 2007 - cell.com
Environmental effects on the materno–foetal interaction determine birth outcomes that
predict health over the lifespan. Thus, maternal undernutrition or stress associate with low …

A meta‐analysis of adverse perinatal outcomes in women with asthma

VE Murphy, JA Namazy, H Powell… - … Journal of Obstetrics …, 2011 - Wiley Online Library
Please cite this paper as: Murphy V, Namazy J, Powell H, Schatz M, Chambers C, Attia J,
Gibson P. A meta‐analysis of adverse perinatal outcomes in women with asthma. BJOG …