Injury of oligodendrocytes (OLs) induces demyelination, and patients with
neurodegenerative diseases exhibit demyelination concomitantly with neurological deficit …

Summary Inappropriate CD4+ T helper (Th) differentiation can compromise host immunity or
promote autoimmune disease. To identify disease-relevant regulators of T cell fate, we …

Experimental autoimmune encephalomyelitis (EAE) is commonly used as an animal model
for evaluating clinical, histological and immunological processes potentially relevant to the …

Gut microbiota has emerged as an important environmental factor in the pathobiology of
multiple sclerosis (MS), an inflammatory demyelinating disease of the central nervous …

The new generation of vaccines for Chagas disease, are focused to induce both humoral
and cellular response to effectively control Trypanosoma cruzi parasites. The administration …

Traumatic spinal cord injury (SCI) is a devastating condition that impacts over 300,000
individuals in the US alone. Depending on the severity of the injury, SCI can lead to varying …

Multiple sclerosis (MS) is a neurological disease featuring neuroinflammation and
neurodegeneration in young adults. So far, most research has focused on the peripheral …

Purpose: Experimental autoimmune encephalomyelitis (EAE) scoring, the most commonly
used primary outcome metric for an in vivo model of multiple sclerosis (MS), is highly …

Crocin is the main bioactive components of the saffron which has positive role in the nervous
system; however, its neuroprotective activity is not fully elicited. So, the aim of the current …

Multiple sclerosis (MS) is a chronic disabling disease of the central nervous system affecting
over 2.5 million people worldwide. Theiler's murine encephalomyelitis virus-induced …