Phosphoinositides (PPIns) are lipid signaling molecules that act as master regulators of
cellular signaling. Recent studies have revealed novel roles of PPIns in myriad cellular …

Endosomes are central protein-sorting stations at the crossroads of numerous membrane
trafficking pathways in all eukaryotes. They have a key role in protein homeostasis and …

Protein trafficking requires coat complexes that couple recognition of sorting motifs in
transmembrane cargoes with biogenesis of transport carriers. The mechanisms of cargo …

Phagocytic clearance of dying cells, termed efferocytosis, is essential for maintaining tissue
homeostasis, yet our understanding of efferocytosis regulation remains incomplete. Here we …

Recycling of membrane proteins enables the reuse of receptors, ion channels and
transporters. A key component of the recycling machinery is the endosomal sorting complex …

The ability of endolysosomal organelles to move within the cytoplasm is essential for the
performance of their functions. Long-range movement involves coupling of the …

Retrograde transport from endosomes to the trans-Golgi network (TGN) diverts proteins and
lipids away from lysosomal degradation. It is essential for maintaining cellular homeostasis …

Retromer is a master regulator of cargo retrieval from endosomes, which is critical for many
cellular processes including signaling, immunity, neuroprotection, and virus infection. The …

We review the use of molecular dynamics (MD) simulation as a drug design tool in the
context of the role that the lipid membrane can play in drug action, ie, the interaction …

Abstract Phosphoinositide 3-kinases (PI3Ks) are lipid kinases that regulate important
intracellular signalling and vesicle trafficking events via the generation of 3 …