The ketogenic diet (KD) is a high-fat, adequate-protein, and very-low-carbohydrate diet
regimen that mimics the metabolism of the fasting state to induce the production of ketone …

The brain is a highly energy-demanding organ and requires bioenergetic adaptability to
balance normal activity with pathophysiological fuelling of spontaneous recurrent seizures …

Under normal physiological conditions the brain primarily utilizes glucose for ATP
generation. However, in situations where glucose is sparse, eg, during prolonged fasting …

Lipids, as the basic component of cell membranes, play an important role in human health
as well as brain function. The brain is highly enriched in lipids, and disruption of lipid …

Background Brain energy metabolism is impaired in Alzheimer's disease (AD), which may
be mitigated by a ketogenic diet. We conducted a randomized crossover trial to determine …

Sarcopenia, an age-related decline in skeletal muscle mass and function, dramatically
affects the quality of life. Although there is a consensus that sarcopenia is a multifactorial …

The Ketogenic Diet (KD) is a modality of treatment used since the 1920s as a treatment for
intractable epilepsy. It has been proposed as a dietary treatment that would produce similar …

Mitochondria maintain the normal physiological function of nerve cells by producing
sufficient cellular energy and performing crucial roles in maintaining the metabolic balance …

Background Systematic reviews and meta-analyses of randomized clinical trials (RCTs)
have reported the benefits of ketogenic diets (KD) in various participants such as patients …

At present, the prevalence of Alzheimer's disease, a devastating neurodegenerative
disorder, is increasing. Although the mechanism of the underlying pathology is not fully …