Autophagy is a highly conserved self-degradative process that has a key role in cellular
stress responses and survival. Recent work has begun to explore the function of autophagy …

In recent years, it has been shown that breast cancer consists not only of neoplastic cells,
but also of significant alterations in the surrounding stroma or tumor microenvironment …

Although survival outcomes of cancer patients have been improved dramatically via
conventional chemotherapy and targeted therapy over the last decades, there are still some …

Aerobic glycolysis, also referred to as the Warburg effect, has been regarded as the
dominant metabolic phenotype in cancer cells for a long time. More recently, it has been …

Here, we propose a new model for understanding the Warburg effect in tumor metabolism.
Our hypothesis is that epithelial cancer cells induce the Warburg effect (aerobic glycolysis) …

Metabolic reprogramming is one of the main characteristics of malignant tumors. The
metabolic reprogramming of tumors is not only related to the characteristics of cancer cells …

Previously, we proposed a new model for understanding the" Warburg effect" in tumor
metabolism. In this scheme, cancer-associated fibroblasts undergo aerobic glycolysis and …

Recently, we proposed a new mechanism for understanding the Warburg effect in cancer
metabolism. In this new paradigm, cancer-associated fibroblasts undergo aerobic glycolysis …

Loss of stromal fibroblast caveolin-1 (Cav-1) is a powerful single independent predictor of
poor prognosis in human breast cancer patients, and is associated with early tumor …

Lipid rafts are tightly packed, cholesterol-and sphingolipid-enriched microdomains within the
plasma membrane that play important roles in many pathophysiologic processes. Rafts have …