The parabrachial nucleus (PB), located in the dorsolateral pons, contains primarily
glutamatergic neurons that regulate responses to a variety of interoceptive and cutaneous …

Introduction This real-world study aimed to investigate the impact of galcanezumab on sleep
quality, migraine outcome and multidimensional patient-reported outcomes measures …

Pain therapies that alleviate both pain and sleep disturbances may be the most effective for
pain relief, as both chronic pain and sleep loss render the opioidergic system, targeted by …

Somatosensation connects animals to their immediate environment, sha** critical
behaviors essential for adaptation, learning, and survival. Probing the relationships between …

Background: Chronic pain, which can fluctuate throughout the day in intensity, contributes to
most years lived with disability worldwide. Whether pain rhythmicity affects biopsychosocial …