The pharmacological management of asthma-chronic obstructive pulmonary disease overlap syndrome (ACOS)
Introduction: Asthma-chronic obstructive pulmonary disease overlap syndrome (ACOS) is a
disease phenotype that shares T helper lymphocyte cell Th1/neutrophilic/non-Type-2 …
disease phenotype that shares T helper lymphocyte cell Th1/neutrophilic/non-Type-2 …
Inhaled steroids, circulating eosinophils, chronic airway infection, and pneumonia risk in chronic obstructive pulmonary disease. A network analysis
Rationale: Treatment of chronic obstructive pulmonary disease (COPD) with inhaled
corticosteroids (ICS) is controversial, because it can reduce the risk of future exacerbations …
corticosteroids (ICS) is controversial, because it can reduce the risk of future exacerbations …
Lung microbiome composition and bronchial epithelial gene expression in patients with COPD versus healthy individuals: a bacterial 16S rRNA gene sequencing and …
MY Ramsheh, K Haldar, A Esteve-Codina… - The Lancet …, 2021 - thelancet.com
Background Chronic obstructive pulmonary disease (COPD) is associated with airway
inflammation and bacterial dysbiosis. The relationship between the airway microbiome and …
inflammation and bacterial dysbiosis. The relationship between the airway microbiome and …
The role of the respiratory microbiome in asthma
CD Campbell, M Gleeson, I Sulaiman - Frontiers in Allergy, 2023 - frontiersin.org
Asthma is a common airways disease and the human microbiome plays an increasingly
recognised role in asthma pathogenesis. Furthermore, the respiratory microbiome varies …
recognised role in asthma pathogenesis. Furthermore, the respiratory microbiome varies …
Relationship between inflammatory status and microbial composition in severe asthma and during exacerbation
Background In T2‐mediated severe asthma, biologic therapies, such as mepolizumab, are
increasingly used to control disease. Current biomarkers can indicate adequate suppression …
increasingly used to control disease. Current biomarkers can indicate adequate suppression …
[HTML][HTML] Blood eosinophil counts in chronic obstructive pulmonary disease: a biomarker of inhaled corticosteroid effects
D Singh - Tuberculosis and respiratory diseases, 2020 - ncbi.nlm.nih.gov
Blood eosinophil counts have emerged as a chronic obstructive pulmonary disease (COPD)
biomarker that predict the effects of inhaled corticosteroids (ICS) in clinical practice. Post-hoc …
biomarker that predict the effects of inhaled corticosteroids (ICS) in clinical practice. Post-hoc …
Targeting eosinophils in respiratory diseases: Biological axis, emerging therapeutics and treatment modalities
Eosinophils are bi-lobed, multi-functional innate immune cells with diverse cell surface
receptors that regulate local immune and inflammatory responses. Several inflammatory and …
receptors that regulate local immune and inflammatory responses. Several inflammatory and …
The relationship between airway immunoglobulin activity and eosinophils in COPD
In chronic obstructive pulmonary disease (COPD), the effects of inhaled corticosteroids are
predicted by blood eosinophil counts. We previously briefly reported increased …
predicted by blood eosinophil counts. We previously briefly reported increased …
[CITATION][C] Airway inflammation in COPD: progress to precision medicine
Deciphering the impact of microbial interactions on COPD exacerbation: An in-depth analysis of the lung microbiome
In microbiome studies, the diversity and types of microbes have been extensively explored;
however, the significance of microbial ecology is equally paramount. The comprehension of …
however, the significance of microbial ecology is equally paramount. The comprehension of …