Mechanisms of SARS-CoV-2 entry into cells

CB Jackson, M Farzan, B Chen, H Choe - Nature reviews Molecular …, 2022 - nature.com
The unprecedented public health and economic impact of the COVID-19 pandemic caused
by infection with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has been …

SARS-CoV-2 immunity: review and applications to phase 3 vaccine candidates

GA Poland, IG Ovsyannikova, RB Kennedy - The Lancet, 2020 - thelancet.com
Understanding immune responses to severe acute respiratory syndrome coronavirus 2 is
crucial to understanding disease pathogenesis and the usefulness of bridge therapies, such …

SARS-CoV-2 spike-protein D614G mutation increases virion spike density and infectivity

L Zhang, CB Jackson, H Mou, A Ojha, H Peng… - Nature …, 2020 - nature.com
SARS-CoV-2 variants with spike (S)-protein D614G mutations now predominate globally.
We therefore compare the properties of the mutated S protein (SG614) with the original …

SARS-CoV-2 binds platelet ACE2 to enhance thrombosis in COVID-19

S Zhang, Y Liu, X Wang, L Yang, H Li, Y Wang… - Journal of hematology & …, 2020 - Springer
Background Critically ill patients diagnosed with COVID-19 may develop a pro-thrombotic
state that places them at a dramatically increased lethal risk. Although platelet activation is …

The trinity of COVID-19: immunity, inflammation and intervention

MZ Tay, CM Poh, L Rénia, PA MacAry… - Nature Reviews …, 2020 - nature.com
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is the causative agent of
the ongoing coronavirus disease 2019 (COVID-19) pandemic. Alongside investigations into …

A vaccine targeting the RBD of the S protein of SARS-CoV-2 induces protective immunity

J Yang, W Wang, Z Chen, S Lu, F Yang, Z Bi, L Bao… - Nature, 2020 - nature.com
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) causes a respiratory
disease called coronavirus disease 2019 (COVID-19), the spread of which has led to a …

Coronavirus disease 2019 (COVID-19): current status and future perspectives

H Li, SM Liu, XH Yu, SL Tang, CK Tang - International journal of …, 2020 - Elsevier
ABSTRACT Coronavirus disease 2019 (COVID-19) originated in the city of Wuhan, Hubei
Province, Central China, and has spread quickly to 72 countries to date. COVID-19 is …

[HTML][HTML] Probable pangolin origin of SARS-CoV-2 associated with the COVID-19 outbreak

T Zhang, Q Wu, Z Zhang - Current biology, 2020 - cell.com
An outbreak of coronavirus disease 2019 (COVID-19) caused by the 2019 novel coronavirus
(SARS-CoV-2) began in the city of Wuhan in China and has widely spread worldwide …

Engineering human ACE2 to optimize binding to the spike protein of SARS coronavirus 2

KK Chan, D Dorosky, P Sharma, SA Abbasi, JM Dye… - Science, 2020 - science.org
The spike (S) protein of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)
binds angiotensin-converting enzyme 2 (ACE2) on host cells to initiate entry, and soluble …

The D614G mutation in the SARS-CoV-2 spike protein reduces S1 shedding and increases infectivity

L Zhang, CB Jackson, H Mou, A Ojha… - BioRxiv, 2020 - pmc.ncbi.nlm.nih.gov
SARS coronavirus 2 (SARS-CoV-2) isolates encoding a D614G mutation in the viral spike
(S) protein predominate over time in locales where it is found, implying that this change …