The ability to control cell volume is pivotal for cell function. Cell volume perturbation elicits a
wide array of signaling events, leading to protective (eg, cytoskeletal rearrangement) and …

Cells in the renal inner medulla are normally exposed to extraordinarily high levels of NaCl
and urea. The osmotic stress causes numerous perturbations because of the hypertonic …

Cell proliferation must–at some time point–lead to increase of cell volume and one of the
hallmarks of apoptosis is cell shrinkage. At constant extracellular osmolarity those …

Erythrocytes lack nuclei and mitochondria, the organelles important for apoptosis of
nucleated cells. However, following increase of cytosolic Ca 2+ activity, erythrocytes …

Cell shrinkage is a hallmark and contributes to signaling of apoptosis. Apoptotic cell
shrinkage requires ion transport across the cell membrane involving K+ channels, Cl− or …

This study demonstrates, by using neutral comet assay and pulsed field gel electrophoresis,
that hyperosmotic stress causes DNA damage in the form of double strand breaks (dsb) …

While hyperosmolality of the kidney medulla is essential for urinary concentration, it imposes
a great deal of stress. Cells in the renal medulla adapt to the stress of hypertonicity …

The ability to control osmotic balance is essential for cellular life. Cellular osmotic
homeostasis is maintained by accumulation and loss of inorganic ions and organic …

Stress, be it from environmental factors or intrinsic to the cell as result of growth and
metabolism can be harmful to cells. Mammalian cells have developed numerous …

Cell shrinkage is a hallmark of the apoptotic mode of programmed cell death, but it is as yet
unclear whether a reduction in cell volume is a primary activation signal of apoptosis. Here …