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Unveiling the role of the Hedgehog signaling pathway in chronic liver disease: therapeutic insights and strategies
Abstract The Hedgehog (Hh) signaling plays a crucial role in adult liver repair by promoting
the expansion and differentiation of hepatic progenitor cells into mature hepatocytes and …
the expansion and differentiation of hepatic progenitor cells into mature hepatocytes and …
Reappraisal of the roles of the Sonic hedgehog signaling pathway in hepatocellular carcinoma
KS Jeng, CF Chang, YM Tsang, IS Sheen, CJ Jeng - Cancers, 2024 - mdpi.com
Simple Summary Hepatocellular carcinoma (HCC) remains one of the leading causes of
cancer mortality. Treatment of HCC remains challenging, especially for those with advanced …
cancer mortality. Treatment of HCC remains challenging, especially for those with advanced …
Targeting Super-Enhancer–Driven Transcriptional Dependencies Suppresses Aberrant Hedgehog Pathway Activation and Overcomes Smoothened Inhibitor …
Y Sui, T Wang, Y Mei, Y Zhu, W Jiang, J Shen… - Cancer …, 2024 - aacrjournals.org
Aberrant activation of the Hedgehog (Hh) signaling pathway plays important roles in
oncogenesis and therapeutic resistance in several types of cancer. The clinical application …
oncogenesis and therapeutic resistance in several types of cancer. The clinical application …
FOXM1-induced TYMS upregulation promotes the progression of hepatocellular carcinoma
L Wang, C Shi, J Yu, Y Xu - Cancer cell international, 2022 - Springer
Background Hepatocellular carcinoma (HCC) is the most common type of primary liver
cancer and one of the major causes of cancer-related death. Thymidylate synthase (TYMS) …
cancer and one of the major causes of cancer-related death. Thymidylate synthase (TYMS) …
TPX2 prompts mitotic survival via the induction of BCL2L1 through YAP1 protein stabilization in human embryonic stem cells
Genetic alterations have been reported for decades in most human embryonic stem cells
(hESCs). Survival advantage, a typical trait acquired during long-term in vitro culture, results …
(hESCs). Survival advantage, a typical trait acquired during long-term in vitro culture, results …
Linear polyubiquitylation of Gli protein regulates its protein stability and facilitates tumor growth in colorectal cancer
J Cheng, L Xu, Y Xuan, F Zhou, A Huang, S Zeng… - Cell Death …, 2024 - nature.com
The linear ubiquitin chain assembly complex (LUBAC) mediates the linear ubiquitination of
various proteins and is involved in NF-κB signaling and immune regulation. However, the …
various proteins and is involved in NF-κB signaling and immune regulation. However, the …
Construction and validation of prognostic signature for hepatocellular carcinoma basing on hepatitis B virus related specific genes
L Wang, M Qiu, L Wu, Z Li, X Meng, L He… - Infectious Agents and …, 2022 - Springer
Background Hepatocellular carcinoma (HCC) is a frequent primary liver cancer, and it is one
of the leading cause of cancer-related deaths. Hepatitis B virus (HBV) infection is a crucial …
of the leading cause of cancer-related deaths. Hepatitis B virus (HBV) infection is a crucial …
Hedgehog− Gli2 signaling promotes chemoresistance in ovarian cancer cells by regulating MDR1
Q Wang, X Wei, L Hu, L Zhuang, H Zhang… - Frontiers in …, 2022 - frontiersin.org
Background Cisplatin (DDP) resistance remains a key challenge in improving the clinical
outcome of patients with ovarian cancer (OC). Gli2 overexpression can lead to DDP …
outcome of patients with ovarian cancer (OC). Gli2 overexpression can lead to DDP …
[HTML][HTML] FOXM1 is a novel molecular target of AFP-positive hepatocellular carcinoma abrogated by proteasome inhibition
R Li, H Okada, T Yamashita, K Nio, H Chen… - International journal of …, 2022 - mdpi.com
Alpha-fetoprotein (AFP) is an oncofetal protein that is elevated in a subset of hepatocellular
carcinoma (HCC) with poor prognosis, but the molecular target activated in AFP-positive …
carcinoma (HCC) with poor prognosis, but the molecular target activated in AFP-positive …
[HTML][HTML] DNAJC5 promotes hepatocellular carcinoma cells proliferation though regulating SKP2 mediated p27 degradation
H Wang, J Luo, X Tian, L Xu, Z Zhai, M Cheng… - … et Biophysica Acta (BBA …, 2021 - Elsevier
DNAJC5 (DnaJ heat shock protein family (Hsp40) member C5), also known as cysteine
tandem protein (CSPα), is important for maintaining the normal function of nerve tissues, but …
tandem protein (CSPα), is important for maintaining the normal function of nerve tissues, but …