Pleiotropic effects of statins on the cardiovascular system
The statins have been used for 30 years to prevent coronary artery disease and stroke. Their
primary mechanism of action is the lowering of serum cholesterol through inhibiting hepatic …
primary mechanism of action is the lowering of serum cholesterol through inhibiting hepatic …
Pleiotropic effects of statins
JK Liao, U Laufs - Annu. Rev. Pharmacol. Toxicol., 2005 - annualreviews.org
▪ Abstract Statins are potent inhibitors of cholesterol biosynthesis. In clinical trials, statins are
beneficial in the primary and secondary prevention of coronary heart disease. However, the …
beneficial in the primary and secondary prevention of coronary heart disease. However, the …
The International Society of Heart and Lung Transplantation Guidelines for the care of heart transplant recipients
MR Costanzo, A Dipchand, R Starling… - The Journal of heart and …, 2010 - Elsevier
CHAIR: Costanzo MR: Midwest Heart Foundation, Lombard Illinois, USA TASK FORCE 1:
Dipchand A: Hospital for Sick Children, Toronto Ontario, Canada; Starling R: Cleveland …
Dipchand A: Hospital for Sick Children, Toronto Ontario, Canada; Starling R: Cleveland …
Small-molecule inhibitors of protein–protein interactions: progressing towards the dream
Protein–protein interactions have a key role in most biological processes, and offer attractive
opportunities for therapeutic intervention. Develo** small molecules that modulate protein …
opportunities for therapeutic intervention. Develo** small molecules that modulate protein …
Inflammation and atherosclerosis
Atherosclerosis, the cause of myocardial infarction, stroke, and ischemic gangrene, is an
inflammatory disease. The atherosclerotic process is initiated when cholesterol-containing …
inflammatory disease. The atherosclerotic process is initiated when cholesterol-containing …
Inflammation in depression and the potential for anti-inflammatory treatment
O Kohler, J Krogh, O Mors… - Current …, 2016 - ingentaconnect.com
Accumulating evidence supports an association between depression and inflammatory
processes, a connection that seems to be bidirectional. Clinical trials have indicated …
processes, a connection that seems to be bidirectional. Clinical trials have indicated …
Efficacy of anti‐inflammatory treatment on major depressive disorder or depressive symptoms: meta‐analysis of clinical trials
O Köhler‐Forsberg, C N. Lydholm… - Acta Psychiatrica …, 2019 - Wiley Online Library
Background No study has gathered evidence from all randomized clinical trials (RCT s) with
anti‐inflammatory drugs measuring antidepressant effects including a detailed assessment …
anti‐inflammatory drugs measuring antidepressant effects including a detailed assessment …
Pleiotropic effects of 3-hydroxy-3-methylglutaryl coenzyme a reductase inhibitors
M Takemoto, JK Liao - Arteriosclerosis, thrombosis, and vascular …, 2001 - Am Heart Assoc
The 3-hydroxy-3-methylglutaryl coenzyme A reductase inhibitors or statins are potent
inhibitors of cholesterol biosynthesis. Several large clinical trials have demonstrated the …
inhibitors of cholesterol biosynthesis. Several large clinical trials have demonstrated the …
Beneficial cardiovascular pleiotropic effects of statins
J Davignon - Circulation, 2004 - Am Heart Assoc
Pleiotropic effects of a drug are actions other than those for which the agent was specifically
developed. These effects may be related or unrelated to the primary mechanism of action of …
developed. These effects may be related or unrelated to the primary mechanism of action of …
Therapeutic strategies for rheumatoid arthritis
JS Smolen, G Steiner - Nature reviews Drug discovery, 2003 - nature.com
Recent years have seen considerable advances in our understanding of both the clinical
and basic-research aspects of rheumatoid arthritis. Clinical progress has come from a better …
and basic-research aspects of rheumatoid arthritis. Clinical progress has come from a better …