The adenosine modulation system mostly operates through inhibitory A1 (A1R) and
facilitatory A2A receptors (A2AR) in the brain. The activity‐dependent release of adenosine …

Adenosine receptors (ARs) comprise a group of G protein-coupled receptors (GPCR) which
mediate the physiological actions of adenosine. To date, four AR subtypes have been …

Extracellular purines (adenosine, ADP, and ATP) and pyrimidines (UDP and UTP) are
important signaling molecules that mediate diverse biological effects via cellsurface …

Intra-and extracellular adenosine levels rise in response to physiological stimuli and with
metabolic/energetic perturbations, inflammatory challenge and tissue injury. Extracellular …

Antagonistic and reciprocal interactions are known to exist between adenosine and
dopamine receptors in the striatum. In the present study, double immunofluorescence …

It is well known that the nucleoside adenosine exerts a modulatory influence in the central
nervous system by activating G protein coupled receptors. Adenosine A2A receptors, the …

Adenosine receptors (ARs) are members of the G protein-coupled receptor family and
mediate the multiple physiological effects of adenosine. Currently, four AR subtypes have …

The ability of the extracellular nucleoside adenosine to regulate metabolism has been
intensively studied since the original description of the cardiovascular effects of adenosine …

Ever since the discovery of the effects of adenosine in the circulation, adenosine receptors
continue to represent a promising drug target. Firstly, this is due to the fact that the receptors …

The distribution, molecular structure and role of adenosine A2 receptors in the nervous
system, is reviewed. The adenosine A2a receptor subtype, identified in the nervous system …