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The genetic landscape of Alzheimer disease
Alzheimer disease (AD), a progressive and neurodegenerative disease, is the most common
form of dementia with high incidence in elderly people. Neuropathologically the disease is …
form of dementia with high incidence in elderly people. Neuropathologically the disease is …
BIN1 is a key regulator of proinflammatory and neurodegeneration-related activation in microglia
Background The BIN1 locus contains the second-most significant genetic risk factor for late-
onset Alzheimer's disease. BIN1 undergoes alternate splicing to generate tissue-and cell …
onset Alzheimer's disease. BIN1 undergoes alternate splicing to generate tissue-and cell …
The Mechanistic Role of Bridging Integrator 1 (BIN1) in Alzheimer's Disease
P Gao, L Ye, H Cheng, H Li - Cellular and Molecular Neurobiology, 2021 - Springer
Alzheimer's disease (AD) is the leading cause of dementia. The majority of AD cases are
late-onset, multifactorial cases. Genome-wide association studies have identified more than …
late-onset, multifactorial cases. Genome-wide association studies have identified more than …
The BIN1 rs744373 SNP is associated with increased tau-PET levels and impaired memory
The single nucleotide polymorphism (SNP) rs744373 in the bridging integrator-1 gene
(BIN1) is a risk factor for Alzheimer's disease (AD). In the brain, BIN1 is involved in …
(BIN1) is a risk factor for Alzheimer's disease (AD). In the brain, BIN1 is involved in …
Loss of forebrain BIN1 attenuates hippocampal pathology and neuroinflammation in a tauopathy model
Abstract Bridging integrator 1 (BIN1) is the second most prevalent genetic risk factor
identified by genome-wide association studies (GWAS) for late-onset Alzheimer's disease …
identified by genome-wide association studies (GWAS) for late-onset Alzheimer's disease …
Reduction of the expression of the late-onset Alzheimer's disease (AD) risk-factor BIN1 does not affect amyloid pathology in an AD mouse model
Alzheimer's disease (AD) is pathologically characterized by the deposition of the β-amyloid
(Aβ) peptide in senile plaques in the brain, leading to neuronal dysfunction and eventual …
(Aβ) peptide in senile plaques in the brain, leading to neuronal dysfunction and eventual …
BIN1 protein isoforms are differentially expressed in astrocytes, neurons, and microglia: neuronal and astrocyte BIN1 are implicated in tau pathology
Abstract Background Identified as an Alzheimer's disease (AD) susceptibility gene by
genome wide-association studies, BIN1 has 10 isoforms that are expressed in the Central …
genome wide-association studies, BIN1 has 10 isoforms that are expressed in the Central …
Bridging integrator 1 protein loss in Alzheimer's disease promotes synaptic tau accumulation and disrupts tau release
EB Glennon, DHW Lau, RMC Gabriele… - Brain …, 2020 - academic.oup.com
Polymorphisms associated with BIN1 (bridging integrator 1) confer the second greatest risk
for develo** late-onset Alzheimer's disease. The biological consequences of this genetic …
for develo** late-onset Alzheimer's disease. The biological consequences of this genetic …
Aberrant accrual of BIN1 near Alzheimer's disease amyloid deposits in transgenic models
Abstract Bridging integrator 1 (BIN1) is the most significant late‐onset Alzheimer's disease
(AD) susceptibility locus identified via genome‐wide association studies. BIN1 is an adaptor …
(AD) susceptibility locus identified via genome‐wide association studies. BIN1 is an adaptor …
The relationship of early-and late-onset Alzheimer's disease genes with COVID-19
Individuals with Alzheimer's disease and other neurodegenerative diseases have been
exposed to excess risk by the COVID-19 pandemic. COVID-19's main manifestations include …
exposed to excess risk by the COVID-19 pandemic. COVID-19's main manifestations include …