Predicting age using neuroimaging: innovative brain ageing biomarkers

JH Cole, K Franke - Trends in neurosciences, 2017 - cell.com
The brain changes as we age and these changes are associated with functional
deterioration and neurodegenerative disease. It is vital that we better understand individual …

Brain age and other bodily 'ages': implications for neuropsychiatry

JH Cole, RE Marioni, SE Harris, IJ Deary - Molecular psychiatry, 2019 - nature.com
As our brains age, we tend to experience cognitive decline and are at greater risk of
neurodegenerative disease and dementia. Symptoms of chronic neuropsychiatric diseases …

Predicting brain age with deep learning from raw imaging data results in a reliable and heritable biomarker

JH Cole, RPK Poudel, D Tsagkrasoulis, MWA Caan… - NeuroImage, 2017 - Elsevier
Abstract Machine learning analysis of neuroimaging data can accurately predict
chronological age in healthy people. Deviations from healthy brain ageing have been …

Factors associated with brain ageing-a systematic review

J Wrigglesworth, P Ward, IH Harding, D Nilaweera… - BMC neurology, 2021 - Springer
Background Brain age is a biomarker that predicts chronological age using neuroimaging
features. Deviations of this predicted age from chronological age is considered a sign of age …

Longitudinal assessment of multiple sclerosis with the brain‐age paradigm

JH Cole, J Raffel, T Friede, A Eshaghi… - Annals of …, 2020 - Wiley Online Library
Objective During the natural course of multiple sclerosis (MS), the brain is exposed to aging
as well as disease effects. Brain aging can be modeled statistically; the so‐called “brain …

Bias-adjustment in neuroimaging-based brain age frameworks: A robust scheme

I Beheshti, S Nugent, O Potvin, S Duchesne - NeuroImage: Clinical, 2019 - Elsevier
The level of prediction error in the brain age estimation frameworks is associated with the
authenticity of statistical inference on the basis of regression models. In this paper, we …

A review of neuroimaging-driven brain age estimation for identification of brain disorders and health conditions

S Mishra, I Beheshti, P Khanna - IEEE Reviews in Biomedical …, 2021 - ieeexplore.ieee.org
Background: Neuroimage analysis has made it possible to perform various anatomical
analyses of the brain regions and helps detect different brain conditions/disorders. Recently …

Brain age estimation from MRI using cascade networks with ranking loss

J Cheng, Z Liu, H Guan, Z Wu, H Zhu… - … on Medical Imaging, 2021 - ieeexplore.ieee.org
Chronological age of healthy people is able to be predicted accurately using deep neural
networks from neuroimaging data, and the predicted brain age could serve as a biomarker …

Biological brain age prediction using machine learning on structural neuroimaging data: Multi-cohort validation against biomarkers of Alzheimer's disease and …

I Cumplido-Mayoral, M García-Prat, G Operto, C Falcon… - Elife, 2023 - elifesciences.org
Brain-age can be inferred from structural neuroimaging and compared to chronological age
(brain-age delta) as a marker of biological brain aging. Accelerated aging has been found in …

Association of relative brain age with tobacco smoking, alcohol consumption, and genetic variants

K Ning, L Zhao, W Matloff, F Sun, AW Toga - Scientific reports, 2020 - nature.com
Brain age is a metric that quantifies the degree of aging of a brain based on whole-brain
anatomical characteristics. While associations between individual human brain regions and …