Tumor microenvironment is a complex system that contains multiple cells and cytokines.
Among the multiple immune cells, macrophage is particularly abundant and plays an …

Since first described by Paul Ehrlich in 1878, mast cells have been mostly viewed as
effectors of allergy. It has been only in the past two decades that mast cells have gained …

Objectives In non‐small cell lung cancer (NSCLC), the immune system and possibly its
composition affect survival. In this in silico study, the immune infiltrate composition in NSCLC …

Tumor metastases are responsible for approximately 90% of all cancer-related deaths.
Although many patients can be cured, in the US and UK, cancer still causes 730,000 deaths …

Cancer creates a complex tumor microenvironment (TME) composed of immune cells,
stromal cells, blood vessels, and various other cellular and extracellular elements. It is …

Mast cells are multifunctional cells that initiate not only IgE-dependent allergic diseases but
also play a fundamental role in innate and adaptive immune responses to microbial …

Tumorigenesis is in many respects a process of dysregulated cellular evolution that drives
malignant cells to acquire six phenotypic hallmarks of cancer, including their ability to …

Mast cells were discovered more than 100 years ago and until recently, have been
considered renegades of the host with the sole purpose of perpetuating allergy. The …

Over recent decades, various studies have argued that the metastatic tissue
microenvironment is fully controlled by the intrinsic properties of the cancer cells (growth …

Just over a century ago Paul Ehrlich received the Nobel Prize for his studies of immunity.
This review describes one of his legacies, the histochemical description of the mast cell, and …