CRISPR-Cas gene editing has revolutionized experimental molecular biology over the past
decade and holds great promise for the treatment of human genetic diseases. Here we …

Guanine-rich nucleic acids can fold into the non-B DNA or RNA structures called G-
quadruplexes (G4). Recent methodological developments have allowed the characterization …

R-loops have both positive and negative impacts on chromosome functions. To identify toxic
R-loops in the human genome, here, we map RNA: DNA hybrids, replication stress markers …

This review focuses on DNA damage caused by a variety of oxidizing, alkylating, and
nitrating species, and it may play an important role in the pathophysiology of inflammation …

To ward off against the catastrophic consequences of persistent DNA double-strand breaks
(DSBs), eukaryotic cells have developed a set of complex signaling networks that detect …

Biological responses to ionizing radiation (IR) have been studied for many years, generally
showing the dependence of these responses on the quality of radiation, ie, the radiation …

As genome-editing nucleases move toward broader clinical applications, the need to define
the limits of their specificity and efficiency increases. A variety of approaches for nuclease …

Although long overlooked, it is now well understood that DNA does not systematically
assemble into a canonical double helix, known as B-DNA, throughout the entire genome but …

Abstract G-quadruplex (G4) is a four-stranded helical DNA secondary structure formed by
guanine-rich sequence folding, and G4 has been computationally predicted to exist in a …

DNA double-strand breaks (DSBs) jeopardize genome integrity and can—when repaired
unfaithfully—give rise to structural rearrangements associated with cancer. Exogenous …