[HTML][HTML] Progress on the prevention and treatment of hantavirus disease

RL Brocato, JW Hooper - Viruses, 2019 - mdpi.com
Hantaviruses, members of the order Bunyavirales, family Hantaviridae, have a world-wide
distribution and are responsible for greater than 150,000 cases of disease per year. The …

Hantavirus: an overview and advancements in therapeutic approaches for infection

S Afzal, L Ali, A Batool, M Afzal, N Kanwal… - Frontiers in …, 2023 - frontiersin.org
Hantaviruses are a significant and emerging global public health threat, impacting more
than 200,000 individuals worldwide each year. The single-stranded RNA viruses belong to …

Structural and mechanistic basis of neutralization by a pan-hantavirus protective antibody

E Mittler, A Serris, ES Esterman, C Florez… - Science translational …, 2023 - science.org
Emerging rodent-borne hantaviruses cause severe diseases in humans with no approved
vaccines or therapeutics. We recently isolated a monoclonal broadly neutralizing antibody …

Vaccines and therapeutics against hantaviruses

R Liu, H Ma, J Shu, Q Zhang, M Han, Z Liu… - Frontiers in …, 2020 - frontiersin.org
Hantaviruses (HVs) are rodent-transmitted viruses that can cause hantavirus
cardiopulmonary syndrome (HCPS) in the Americas and hemorrhagic fever with renal …

Hantavirus entry: Perspectives and recent advances

E Mittler, ME Dieterle, LM Kleinfelter, MM Slough… - Advances in virus …, 2019 - Elsevier
Hantaviruses are important zoonotic pathogens of public health importance that are found
on all continents except Antarctica and are associated with hemorrhagic fever with renal …

Human antibody recognizing a quaternary epitope in the Puumala virus glycoprotein provides broad protection against orthohantaviruses

E Mittler, AZ Wec, J Tynell, P Guardado-Calvo… - Science translational …, 2022 - science.org
The rodent-borne hantavirus Puumala virus (PUUV) and related agents cause hemorrhagic
fever with renal syndrome (HFRS) in humans. Other hantaviruses, including Andes virus …

Hantavirus infections—treatment and prevention

K Dheerasekara, S Sumathipala… - Current treatment options …, 2020 - Springer
Purpose of review Hantavirus infection is an emerging zoonosis and there are two main
clinical presentations, hemorrhagic fever with renal syndrome (HFRS) and Hantavirus …

Comparison of uridine and N1-methylpseudouridine mRNA platforms in development of an Andes virus vaccine

IV Kuzmin, R Soto Acosta, L Pruitt, PT Wasdin… - Nature …, 2024 - nature.com
The rodent-borne Andes virus (ANDV) causes a severe disease in humans. We developed
an ANDV mRNA vaccine based on the M segment of the viral genome, either with regular …

Hantavirus diseases pathophysiology, their diagnostic strategies and therapeutic approaches: A review

N Munir, M Jahangeer, S Hussain… - Clinical and …, 2021 - Wiley Online Library
Hantaviruses are enveloped negative (−) single‐stranded RNA viruses belongs to
Hantaviridae family, hosted by small rodents and entering into the human body through …

Broad and potently neutralizing monoclonal antibodies isolated from human survivors of New World hantavirus infection

TB Engdahl, NA Kuzmina, AJ Ronk, CE Mire, MA Hyde… - Cell reports, 2021 - cell.com
Summary New World hantaviruses (NWHs) are endemic in North and South America and
cause hantavirus cardiopulmonary syndrome (HCPS), with a case fatality rate of up to 40 …