[HTML][HTML] Proteoglycan form and function: A comprehensive nomenclature of proteoglycans
We provide a comprehensive classification of the proteoglycan gene families and respective
protein cores. This updated nomenclature is based on three criteria: Cellular and subcellular …
protein cores. This updated nomenclature is based on three criteria: Cellular and subcellular …
The extracellular matrix and pancreatic cancer: a complex relationship
M Weniger, KC Honselmann, AS Liss - Cancers, 2018 - mdpi.com
Pancreatic ductal adenocarcinoma (PDAC) has an extraordinarily dense fibrotic stroma that
impedes tumor perfusion and delivery of anticancer drugs. Since the extracellular matrix …
impedes tumor perfusion and delivery of anticancer drugs. Since the extracellular matrix …
Extracellular matrices and cancer-associated fibroblasts: targets for cancer diagnosis and therapy?
I Belhabib, S Zaghdoudi, C Lac, C Bousquet, C Jean - Cancers, 2021 - mdpi.com
Simple Summary Stroma modifications observed in solid cancer are now recognized as
critical events for cancer progression and as potential therapeutic or diagnostic targets. The …
critical events for cancer progression and as potential therapeutic or diagnostic targets. The …
The PDAC extracellular matrix: a review of the ECM protein composition, tumor cell interaction, and therapeutic strategies
Pancreatic ductal adenocarcinoma (PDAC) is notorious for a dense fibrotic stroma that is
interlaced with a collagen-based extracellular matrix (ECM) that plays an important role in …
interlaced with a collagen-based extracellular matrix (ECM) that plays an important role in …
Deregulation of ribosomal proteins in human cancers
W El Khoury, Z Nasr - Bioscience Reports, 2021 - portlandpress.com
The ribosome, the site for protein synthesis, is composed of ribosomal RNAs (rRNAs) and
ribosomal proteins (RPs). The latter have been shown to have many ribosomal and …
ribosomal proteins (RPs). The latter have been shown to have many ribosomal and …
The glycosylation landscape of pancreatic cancer
J Munkley - Oncology Letters, 2019 - spandidos-publications.com
Pancreatic adenocarcinoma is a lethal disease with a 5‑year survival rate of< 5%, the lowest
of all types of cancer. The diagnosis of pancreatic cancer relies on imaging and tissue …
of all types of cancer. The diagnosis of pancreatic cancer relies on imaging and tissue …
The extracellular matrix: a key accomplice of cancer stem cell migration, metastasis formation, and drug resistance in PDAC
D Wang, Y Li, H Ge, T Ghadban, M Reeh, C Guengoer - Cancers, 2022 - mdpi.com
Simple Summary This review takes the extracellular matrix (ECM) as the starting point, and
describes its influence and related mechanisms on the biological behavior of pancreatic …
describes its influence and related mechanisms on the biological behavior of pancreatic …
Disrupting glutamine metabolic pathways to sensitize gemcitabine-resistant pancreatic cancer
R Chen, LA Lai, Y Sullivan, M Wong, L Wang… - Scientific reports, 2017 - nature.com
Pancreatic cancer is a lethal disease with poor prognosis. Gemcitabine has been the first
line systemic treatment for pancreatic cancer. However, the rapid development of drug …
line systemic treatment for pancreatic cancer. However, the rapid development of drug …
[HTML][HTML] Key biological processes driving metastatic spread of pancreatic cancer as identified by multi-omics studies
TYS Le Large, MF Bijlsma, G Kazemier… - Seminars in cancer …, 2017 - Elsevier
Pancreatic ductal adenocarcinoma (PDAC) is an extremely aggressive malignancy,
characterized by a high metastatic burden, already at the time of diagnosis. The metastatic …
characterized by a high metastatic burden, already at the time of diagnosis. The metastatic …
Long-term survival in patients with pancreatic ductal adenocarcinoma
Background Long-term survival (LTS) is uncommon for patients with pancreatic ductal
adenocarcinoma (PDAC). We sought to identify factors that predict 10-year, LTS after …
adenocarcinoma (PDAC). We sought to identify factors that predict 10-year, LTS after …