Osteoarthritis comprises several joint disorders characterized by articular cartilage
degeneration and persistent pain, causing disability and economic burden. The incidence of …

Articular cartilage shows limited self-healing ability owing to its low cellularity and
avascularity. Untreated cartilage defects display an increased propensity to degenerate …

There is emerging awareness that subchondral bone remodeling plays an important role in
the development of osteoarthritis (OA). This review presents recent investigations on the …

Osteoarthritis (OA) is the most common form of arthritic disease, leading to disability and
impaired quality of life and no curative treatments exist. Increasing evidence indicates that …

Osteoarthritis (OA), long considered a primary disorder of articular cartilage, is commonly
associated with subchondral bone sclerosis. However, the cellular mechanisms responsible …

Rheumatoid arthritis and osteoarthritis, the most common forms of arthritis, are chronic,
painful, and disabling conditions. Although both diseases differ in etiology, they manifest in …

The bidirectional relationship between osteochondral defects (OCD) and osteoarthritis (OA),
with each condition exacerbating the other, makes OCD regeneration in the presence of OA …

Molecular understanding of osteoarthritis (OA) has greatly increased over the past 15 years
through careful analysis of tissue samples, pre-clinical models and large-scale agnostic '∼ …

Osteoarthritis (OA) and osteoporosis (OP) are two skeletal disorders associated with joint
structures. Occasionally, OA and OP occur in the same patient. However, the effect of OP …

Osteoarthritis (OA) is an entire joint disease with pathological alteration in both articular
cartilage and subchondral bone. It has been recognized recently the association between …