The same genetic variant found in different individuals can cause a range of diverse
phenotypes, from no discernible clinical phenotype to severe disease, even among related …

Recent genome-wide studies have reported novel associations between common
polymorphisms and susceptibility to many major infectious diseases in humans. In parallel …

Eukaryotic cells rapidly reduce protein synthesis in response to various stress conditions.
This can be achieved by the phosphorylation-mediated inactivation of a key translation …

Myelofibrosis is a severe myeloproliferative neoplasm characterized by increased numbers
of abnormal bone marrow megakaryocytes that induce fibrosis, destroying the hematopoietic …

Chronic lung disease determines the morbidity and mortality of cystic fibrosis (CF) patients.
The pulmonary immune response in CF is characterized by an early and non-resolving …

In the past three decades, scientists have had immense success in identifying genes and
their variants that contribute to an array of diseases. While the identification of such genetic …

Genetically modified mice have been studied for more than fifteen years as models of cystic
fibrosis (CF). The large amount of experimental data generated illuminates the complex …

Ethnopharmacological relevance Pulmonary fibrosis (PF) is a chronic, debilitating and often
lethal lung disorder. Despite the molecular mechanisms of PF are gradually clear with …

By the late 1980s, it was clear that allergic diseases, including asthma, eczema, allergic
rhinitis and food allergy, had been increasing in recent decades, but the extent of this …

Soon, the genetic basis of most human Mendelian diseases will be solved. The next
challenge will be to leverage this information to uncover basic mechanisms of disease and …