Increased glucose metabolism and uptake are characteristic of many tumors and used
clinically to diagnose and monitor cancer progression. In addition to cancer cells, the tumor …

The extracellular matrix is a fundamental, core component of all tissues and organs, and is
essential for the existence of multicellular organisms. From the earliest stages of organism …

Cancer-associated fibroblasts (CAFs) are a key component of the tumour microenvironment
with diverse functions, including matrix deposition and remodelling, extensive reciprocal …

The extracellular matrix (ECM) is a ubiquitous member of the body and is key to the
maintenance of tissue and organ integrity. Initially thought to be a bystander in many cellular …

Cancer-associated fibroblasts (CAFs) are major components of the carcinoma
microenvironment that promote tumor progression. However, the mechanisms by which …

Physical changes in skin are among the most visible signs of aging. We found that young
dermal fibroblasts secrete high levels of extracellular matrix (ECM) constituents, including …

Extracellular matrix (ECM) derived components are emerging sources for the engineering of
biomaterials that are capable of inducing desirable cell-specific responses. This review …

Much of our understanding of the biological mechanisms that underlie cellular functions,
such as migration, differentiation and force-sensing has been garnered from studying cells …

Metastasis formation is a complex multistep process that requires cancer cells to move from
their tissue of origin to neighboring and distant organs (Joyce and Pollard, 2009; Wirtz et al …

Cell migration is fundamental to establishing and maintaining the proper organization of
multicellular organisms. Morphogenesis can be viewed as a consequence, in part, of cell …