Molecular mechanisms of antibiotic resistance revisited

EM Darby, E Trampari, P Siasat, MS Gaya… - Nature Reviews …, 2023 - nature.com
Antibiotic resistance is a global health emergency, with resistance detected to all antibiotics
currently in clinical use and only a few novel drugs in the pipeline. Understanding the …

Pseudomonas aeruginosa: pathogenesis, virulence factors, antibiotic resistance, interaction with host, technology advances and emerging therapeutics

S Qin, W ** soil resistome revealed by metagenomic analysis
Z Liu, Y Zhao, B Zhang, J Wang, L Zhu… - Environmental science & …, 2023 - ACS Publications
Soil is recognized as the major reservoir of antibiotic resistance genes (ARGs), harboring
the most diverse naturally evolved ARGs on the planet. Multidrug resistance genes are a …

AcrAB− TolC, a major efflux pump in Gram negative bacteria: toward understanding its operation mechanism

S Jang - BMB reports, 2023 - pmc.ncbi.nlm.nih.gov
Antibiotic resistance (AR) is a silent pandemic that kills millions worldwide. Although the
development of new therapeutic agents against antibiotic resistance is in urgent demand …

Campylobacter jejuni in Poultry: Pathogenesis and Control Strategies

WG Al Hakeem, S Fathima, R Shanmugasundaram… - Microorganisms, 2022 - mdpi.com
C. jejuni is the leading cause of human foodborne illness associated with poultry, beef, and
pork consumption. C. jejuni is highly prevalent in commercial poultry farms, where horizontal …

Allosteric drug transport mechanism of multidrug transporter AcrB

HK Tam, WE Foong, C Oswald, A Herrmann… - Nature …, 2021 - nature.com
Gram-negative bacteria maintain an intrinsic resistance mechanism against entry of noxious
compounds by utilizing highly efficient efflux pumps. The E. coli AcrAB-TolC drug efflux …

Ever-adapting RND efflux pumps in gram-negative multidrug-resistant pathogens: a race against time

M Zwama, K Nishino - Antibiotics, 2021 - mdpi.com
The rise in multidrug resistance (MDR) is one of the greatest threats to human health
worldwide. MDR in bacterial pathogens is a major challenge in healthcare, as bacterial …

Bdellovibrio predation cycle characterized at nanometre-scale resolution with cryo-electron tomography

M Kaplan, YW Chang, CM Oikonomou, WJ Nicolas… - Nature …, 2023 - nature.com
Bdellovibrio bacteriovorus is a microbial predator that offers promise as a living antibiotic for
its ability to kill Gram-negative bacteria, including human pathogens. Even after six decades …