Krüppel-like factor 4 (KLF4): What we currently know

AM Ghaleb, VW Yang - Gene, 2017 - Elsevier
Krüppel-like factor 4 (KLF4) is an evolutionarily conserved zinc finger-containing
transcription factor that regulates diverse cellular processes such as cell growth …

KLF4 transcription factor in tumorigenesis

Z He, J He, K **e - Cell death discovery, 2023 - nature.com
Krüppel-like transcriptional factor is important in maintaining cellular functions. Deletion of
Krüppel-like transcriptional factor usually causes abnormal embryonic development and …

Epithelial to mesenchymal transition: a mechanism that fuels cancer radio/chemoresistance

J Dudás, A Ladányi, J Ingruber, TB Steinbichler… - Cells, 2020 - mdpi.com
Epithelial to mesenchymal transition (EMT) contributes to tumor progression, cancer cell
invasion, and therapy resistance. EMT is regulated by transcription factors such as the …

CircPLEKHM3 acts as a tumor suppressor through regulation of the miR-9/BRCA1/DNAJB6/KLF4/AKT1 axis in ovarian cancer

L Zhang, Q Zhou, Q Qiu, L Hou, M Wu, J Li, X Li, B Lu… - Molecular Cancer, 2019 - Springer
Background Emerging evidence has shown that circular RNAs (circRNAs) play essential
roles in cancer biology and are potential biomarkers and targets for cancer therapy …

Harnessing function of EMT in cancer drug resistance: a metastasis regulator determines chemotherapy response

N Ebrahimi, MS Manavi, F Faghihkhorasani… - Cancer and Metastasis …, 2024 - Springer
Epithelial-mesenchymal transition (EMT) is a complicated molecular process that governs
cellular shape and function changes throughout tissue development and embryogenesis. In …

The role of cytokines in epithelial–mesenchymal transition in gynaecological cancers: a systematic review

I Ray, A Michael, LB Meira, PE Ellis - Cells, 2023 - mdpi.com
Chronic inflammation has been closely linked to the development and progression of
various cancers. The epithelial–mesenchymal transition (EMT) is a process involving the …

Epithelial-to-mesenchymal transition in the female reproductive tract: from normal functioning to disease pathology

O Bilyk, M Coatham, M Jewer, LM Postovit - Frontiers in oncology, 2017 - frontiersin.org
Epithelial-to-mesenchymal transition (EMT) is a physiological process that is vital throughout
the human lifespan. In addition to contributing to the development of various tissues within …

[HTML][HTML] Exosomes as mediators of platinum resistance in ovarian cancer

J Crow, S Atay, S Banskota, B Artale, S Schmitt… - Oncotarget, 2017 - ncbi.nlm.nih.gov
Exosomes have been implicated in the cell-cell transfer of oncogenic proteins and genetic
material. We speculated this may be one mechanism by which an intrinsically platinum …

[HTML][HTML] Knockout of MTF1 inhibits the epithelial to mesenchymal transition in ovarian cancer cells

L Ji, G Zhao, P Zhang, W Huo, P Dong, H Watari… - Journal of …, 2018 - ncbi.nlm.nih.gov
Due to peritoneal metastasis and frequent recurrence, ovarian cancer has the highest
mortality among gynecological cancers. Epithelial to mesenchymal transition (EMT) …

miR-203 inhibits ovarian tumor metastasis by targeting BIRC5 and attenuating the TGFβ pathway

B Wang, X Li, G Zhao, H Yan, P Dong, H Watari… - Journal of Experimental …, 2018 - Springer
Background We previously reported that miR-203 functions as a tumor suppressor in
ovarian cancer cells by directly targeting transcription factor Snai2 and inhibiting epithelial to …