Molecular basis of human sperm capacitation

LC Puga Molina, GM Luque, PA Balestrini… - Frontiers in cell and …, 2018 - frontiersin.org
In the early 1950s, Austin and Chang independently described the changes that are
required for the sperm to fertilize oocytes in vivo. These changes were originally grouped …

Calcium channels in the development, maturation, and function of spermatozoa

A Darszon, T Nishigaki, C Beltran… - Physiological …, 2011 - journals.physiology.org
A proper dialogue between spermatozoa and the egg is essential for conception of a new
individual in sexually reproducing animals. Ca2+ is crucial in orchestrating this unique event …

[HTML][HTML] Structural diversity of axonemes across mammalian motile cilia

MR Leung, C Sun, J Zeng, JR Anderson, Q Niu… - Nature, 2025 - nature.com
Reproduction, development and homeostasis depend on motile cilia, whose rhythmic
beating is powered by a microtubule-based molecular machine called the axoneme …

Control of hyperactivation in sperm

SS Suarez - Human reproduction update, 2008 - academic.oup.com
BACKGROUND Sperm hyperactivation is critical to fertilization, because it is required for
penetration of the zona pellucida. Hyperactivation may also facilitate release of sperm from …

Major regulatory mechanisms involved in sperm motility

R Pereira, R Sá, A Barros, M Sousa - Asian Journal of Andrology, 2017 - journals.lww.com
The genetic bases and molecular mechanisms involved in the assembly and function of the
flagellum components as well as in the regulation of the flagellar movement are not fully …

[HTML][HTML] Ion channels, phosphorylation and mammalian sperm capacitation

PE Visconti, D Krapf, JL De La Vega-beltrán… - Asian journal of …, 2011 - ncbi.nlm.nih.gov
Sexually reproducing animals require an orchestrated communication between
spermatozoa and the egg to generate a new individual. Capacitation, a maturational …

Moving to the beat: a review of mammalian sperm motility regulation

RM Turner - Reproduction, Fertility and Development, 2005 - CSIRO Publishing
Because it is generally accepted that a high percentage of poorly motile or immotile sperm
will adversely affect male fertility, analysis of sperm motility is a central part of the evaluation …

Protein signatures of seminal plasma from bulls with contrasting frozen-thawed sperm viability

FP Gomes, R Park, AG Viana, C Fernandez-Costa… - Scientific Reports, 2020 - nature.com
The present study investigated the seminal plasma proteome of Holstein bulls with low (LF;
n= 6) and high (HF; n= 8) sperm freezability. The percentage of viable frozen-thawed sperm …

Biphasic role of calcium in mouse sperm capacitation signaling pathways

FA Navarrete, FA García‐Vázquez… - Journal of cellular …, 2015 - Wiley Online Library
Mammalian sperm acquire fertilizing ability in the female tract in a process known as
capacitation. At the molecular level, capacitation is associated with up‐regulation of a cAMP …

Signal transduction pathways that regulate sperm capacitation and the acrosome reaction

A Abou-haila, DRP Tulsiani - Archives of biochemistry and biophysics, 2009 - Elsevier
Ejaculated spermatozoa must undergo physiological priming as they traverse the female
reproductive tract before they can bind to the egg's extracellular coat, the zona pellucida …