The field of Brillouin microscopy and imaging was established approximately 20 years ago,
thanks to the development of non-scanning high-resolution optical spectrometers. Since …

The optical microscope has revolutionized biology since at least the 17th Century. Since
then, it has progressed from a largely observational tool to a powerful bioanalytical platform …

Long-term observation of subcellular dynamics in living organisms is limited by background
fluorescence originating from tissue scattering or dense labeling. Existing confocal …

Light-sheet fluorescence microscopy has transformed our ability to visualize and
quantitatively measure biological processes rapidly and over long time periods. In this …

For generations researchers have been observing the dynamic processes of life through the
lens of a microscope. This has offered tremendous insights into biological phenomena that …

Electrochemiluminescence (ECL) is rapidly evolving from an analytical method into an
optical microscopy. The orthogonality of the electrochemical trigger and the optical readout …

Light-sheet fluorescence microscopy (LSFM) is a widely used technique for imaging cleared
tissue and living samples. However, high-performance LSFM systems are typically …

Structured illumination microscopy (SIM) doubles the spatial resolution of a fluorescence
microscope without requiring high laser powers or specialized fluorophores. However, the …

As miniaturized and simplified stem cell-derived 3D organ-like structures, organoids are
rapidly emerging as powerful tools for biomedical applications. With their potential for …

Holistic understanding of physio-pathological processes requires noninvasive 3D imaging in
deep tissue across multiple spatial and temporal scales to link diverse transient subcellular …