Cytokine storm generates during various systemic acute infections, including sepsis and
current pandemic called COVID-19 (severe) causing devastating inflammatory conditions …

The extracellular forms of the IL‐1 cytokines are active through binding to specific receptors
on the surface of target cells. IL‐1 ligands bind to the extracellular portion of their ligand …

Advancing our understanding of mechanisms of immune regulation in allergy, asthma,
autoimmune diseases, tumor development, organ transplantation, and chronic infections …

The innate immune system in drosophila and mammals senses the invasion of
microorganisms using the family of Toll receptors, stimulation of which initiates a range of …

Cytokines of the interleukin-1 (IL-1) family, such as IL-1α/β and IL-18, have important
functions in host defense, immune regulation, and inflammation. Insight into their biological …

Three contradictory clinical presentations of gout have puzzled clinicians and basic
scientists for some time: first, the crescendo of sterile inflammation in acute gouty arthritis; …

IL-33, a member of the IL-1-related cytokines, is considered to be a proallergic cytokine that
is especially involved in Th2-type immune responses. Moreover, like IL-1α, IL-33 has been …

For many years, the interleukin-1 receptor family member ST2 was an orphan receptor that
was studied in the context of inflammatory and autoimmune disease. However, in 2005, a …

Abstract Interleukin-33 (IL-33) is a member of the IL-1 family and plays an ambivalent role in
autoimmune diseases. IL-33 signals via the ST2 receptor and drives cytokine production in …

Toll-like receptors (TLRs) are involved in host defence against invading pathogens,
functioning as primary sensors of microbial products and activating signalling pathways that …