Molecular docking has been widely employed as a fast and inexpensive technique in the
past decades, both in academic and industrial settings. Although this discipline has now had …

Fragment-based drug discovery typically requires an interplay between screening methods,
structural methods, and medicinal chemistry. X-ray crystallography is generally the method …

TP53 is universally recognized as a pivotal protein in cell-cycle fate and apoptotic induction
and, unsurprisingly, it is one of the most commonly hijacked control mechanisms in cancer …

The c-Jun NH2-terminal kinase (JNK) signaling pathway is central to the cell response to
stress, inflammatory signals, and toxins. While selective inhibitors are known for JNKs and …

Cardioprotective effects of dietary anthocyanins are partly attributed to their ability to
maintain endothelial function. However, the underlying cellular and molecular mechanisms …

The popularity of fragment-based drug discovery (FBDD) is demonstrated by the number of
recent successful fragment-to-lead (F2L) publications. This Miniperspective provides a …

Lung cancer (LC) is a highly invasive malignancy and the leading cause of cancer-related
deaths, with non-small cell lung cancer (NSCLC) as its most prevalent histological subtype …

Colorectal cancer (CRC) is one of the most common malignant tumors worldwide and
understanding its underlying molecular mechanisms is crucial for the development of …

The androgen receptor (AR) signalling pathway is the key driver in most prostate cancers
(PCa), and is underpinned by several kinases both upstream and downstream of the AR …

Background Colorectal cancer (CRC) is the third most common type of cancer and the
second leading cause of cancer-related deaths worldwide, with a survival rate near to 10 …