Medicinal inorganic chemistry offers additional opportunities for the design of therapeutic
agents not accessible to organic compounds. 1− 3 The wide range of coordination numbers …

Copper serves as a vital microelement which is widely present in the biosystem, functioning
as multi-enzyme active site, including oxidative stress, lipid oxidation and energy …

Copper is found in all living organisms and is a crucial trace element in redox chemistry,
growth and development. It is important for the function of several enzymes and proteins …

Metal-based antitumor drugs play a relevant role in antiblastic chemotherapy. Cisplatin is
regarded as one of the most effective drugs, even if severe toxicities and drug resistance …

This critical review is an updated survey of metal–carbenes as potential anticancer
chemotherapeutics. We report on the recent advances in the discovery of N-heterocyclic …

The chemical properties of copper allow it to take part in many biological functions such as
electron transfer, catalysis, and structural sha**. The ability to cycle between+ 1 and+ 2 …

New weapons to fight cancer are constantly needed. Among chemotherapeutics, anti-cancer
metal-drugs have enjoyed a long and successful history since the discovery of the …

To develop potential next-generation metal anticancer agents, we designed and
synthesised five Cu (II) 2-pyridine-thiosemicarbazone complexes by modifying the hydrogen …

Platinum anticancer drugs have been used for three decades despite their serious side
effects and the emerging of resistance phenomena. Recently, a phosphine copper (I) …

Tetrahedral copper (I) TpCuP complexes 1–15, where Tp is a N, N, N-tris (azolyl) borate and
P is a tertiary phosphine, have been synthesized and characterized by means of NMR, ESI …