Progress, opportunities, and challenges of troponin analysis in the early diagnosis of cardiovascular diseases

X Du, X Su, W Zhang, S Yi, G Zhang, S Jiang… - Analytical …, 2021 - ACS Publications
Cardiovascular diseases (CVD) have one of the leading mortalities throughout the world; an
estimated 17.9 million people died from CVD in 2019, representing 32% of all global deaths …

NIR-responsive gold nanomaterials in photothermal antibacterial therapy: From morphological design to multifunctional platforms

J Gong, Q Ding, Y Shi, M Li, C Liu, W Zeng… - Coordination Chemistry …, 2025 - Elsevier
The prevailing strategies for treating bacterial infections predominantly utilize traditional
antibiotics, leading to the proliferation of drug-resistant bacteria. These bacteria significantly …

Quantification of available ligand density on the surface of targeted liposomal nanomedicines at the single-particle level

C Chen, Y Zhou, C Chen, S Zhu, X Yan - ACS nano, 2022 - ACS Publications
Active targeting has been hailed as one of the most promising strategies to further enhance
the therapeutic efficacy of liposomal nanomedicines. Owing to the critical role of ligand …

Rate-Engineered Plasmon-Enhanced Fluorescence for Real-Time Microsecond Dynamics of Single Biomolecules

SW Nooteboom, KR Okholm, V Lamberti, B Oomen… - Nano Letters, 2024 - ACS Publications
Single-molecule fluorescence has revealed a wealth of biochemical processes but does not
give access to submillisecond dynamics involved in transient interactions and molecular …

Correlating super-resolution microscopy and transmission electron microscopy reveals multiparametric heterogeneity in nanoparticles

T Andrian, P Delcanale, S Pujals, L Albertazzi - Nano Letters, 2021 - ACS Publications
The functionalization of nanoparticles with functional moieties is a key strategy to achieve
cell targeting in nanomedicine. The interplay between size and ligand number is crucial for …

Map** antibody domain exposure on nanoparticle surfaces using dna-paint

MME Tholen, BJHM Rosier, RT Vermathen… - ACS …, 2023 - ACS Publications
Decorating nanoparticles with antibodies (Ab) is a key strategy for targeted drug delivery
and imaging. For this purpose, the orientation of the antibody on the nanoparticle is crucial …

Single-Molecule Multivalent Interactions Revealed by Plasmon-Enhanced Fluorescence

KR Okholm, SW Nooteboom, JN Vinther, V Lamberti… - ACS …, 2024 - ACS Publications
Multivalency as an interaction principle is widely utilized in nature. It enables specific and
strong binding by multiple weak interactions through enhanced avidity and is a core process …

(In) stability of ligands at the surface of inorganic nanoparticles: A forgotten question in nanomedicine?

M Le Goas, J Saber, SG Bolivar, JM Rabanel… - Nano Today, 2022 - Elsevier
Multiple inorganic nanoparticles (NPs) are currently being developed for nanomedicine.
Various core materials and shapes are explored, but they all display a common hybrid …

Plasmonic Assemblies for Real‐Time Single‐Molecule Biosensing

RE Armstrong, M Horáček, P Zijlstra - Small, 2020 - Wiley Online Library
Their tunable optical properties and versatile surface functionalization have sparked
applications of plasmonic assemblies in the fields of biosensing, nonlinear optics, and …

Real‐Time Interfacial Nanothermometry Using DNA‐PAINT Microscopy

SW Nooteboom, Y Wang, S Dey, P Zijlstra - Small, 2022 - Wiley Online Library
Biofunctionalized nanoparticles are increasingly used in biomedical applications including
sensing, targeted delivery, and hyperthermia. However, laser excitation and associated …