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Functions and consequences of AID/APOBEC-mediated DNA and RNA deamination
The AID/APOBEC polynucleotide cytidine deaminases have historically been classified as
either DNA mutators or RNA editors based on their first identified nucleic acid substrate …
either DNA mutators or RNA editors based on their first identified nucleic acid substrate …
[HTML][HTML] APOBECs and virus restriction
The APOBEC family of single-stranded DNA cytosine deaminases comprises a formidable
arm of the vertebrate innate immune system. Pre-vertebrates express a single APOBEC …
arm of the vertebrate innate immune system. Pre-vertebrates express a single APOBEC …
HIV infects astrocytes in vivo and egresses from the brain to the periphery
HIV invades the brain during acute infection. Yet, it is unknown whether long-lived infected
brain cells release productive virus that can egress from the brain to re-seed peripheral …
brain cells release productive virus that can egress from the brain to re-seed peripheral …
HIV-1 and SARS-CoV-2: Patterns in the evolution of two pandemic pathogens
Humanity is currently facing the challenge of two devastating pandemics caused by two very
different RNA viruses: HIV-1, which has been with us for decades, and SARS-CoV-2, which …
different RNA viruses: HIV-1, which has been with us for decades, and SARS-CoV-2, which …
[HTML][HTML] Redefining the viral reservoirs that prevent HIV-1 eradication
E Eisele, RF Siliciano - Immunity, 2012 - cell.com
This Perspective proposes definitions for key terms in the field of HIV-1 latency and
eradication. In the context of eradication, a reservoir is a cell type that allows persistence of …
eradication. In the context of eradication, a reservoir is a cell type that allows persistence of …
HIV restriction factors and mechanisms of evasion
Retroviruses have long been a fertile model for discovering host–pathogen interactions and
their associated biological principles and processes. These advances have not only …
their associated biological principles and processes. These advances have not only …
HIV-1 and interferons: who's interfering with whom?
The ability of interferons (IFNs) to inhibit HIV-1 replication in cell culture models has long
been recognized, and the therapeutic administration of IFNα to HIV-1-infected patients who …
been recognized, and the therapeutic administration of IFNα to HIV-1-infected patients who …
Genetic identity, biological phenotype, and evolutionary pathways of transmitted/founder viruses in acute and early HIV-1 infection
Identification of full-length transmitted HIV-1 genomes could be instrumental in HIV-1
pathogenesis, microbicide, and vaccine research by enabling the direct analysis of those …
pathogenesis, microbicide, and vaccine research by enabling the direct analysis of those …
Generation of transmitted/founder HIV-1 infectious molecular clones and characterization of their replication capacity in CD4 T lymphocytes and monocyte-derived …
Genome sequences of transmitted/founder (T/F) HIV-1 have been inferred by analyzing
single genome amplicons of acute infection plasma viral RNA in the context of a …
single genome amplicons of acute infection plasma viral RNA in the context of a …
[HTML][HTML] Perspective: APOBEC mutagenesis in drug resistance and immune escape in HIV and cancer evolution
The apolipoprotein B mRNA-editing enzyme, catalytic polypeptide-like (APOBEC)
mutational signature has only recently been detected in a multitude of cancers through next …
mutational signature has only recently been detected in a multitude of cancers through next …