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SARS-CoV-2 and innate immunity: the good, the bad, and the “goldilocks”
An ancient conflict between hosts and pathogens has driven the innate and adaptive arms of
immunity. Knowledge about this interplay can not only help us identify biological …
immunity. Knowledge about this interplay can not only help us identify biological …
A-to-I RNA editing—immune protector and transcriptome diversifier
Modifications of RNA affect its function and stability. RNA editing is unique among these
modifications because it not only alters the cellular fate of RNA molecules but also alters …
modifications because it not only alters the cellular fate of RNA molecules but also alters …
Evidence for host-dependent RNA editing in the transcriptome of SARS-CoV-2
The COVID-19 outbreak has become a global health risk, and understanding the response
of the host to the SARS-CoV-2 virus will help to combat the disease. RNA editing by host …
of the host to the SARS-CoV-2 virus will help to combat the disease. RNA editing by host …
Direct identification of A-to-I editing sites with nanopore native RNA sequencing
Inosine is a prevalent RNA modification in animals and is formed when an adenosine is
deaminated by the ADAR family of enzymes. Traditionally, inosines are identified indirectly …
deaminated by the ADAR family of enzymes. Traditionally, inosines are identified indirectly …
Gene regulation in the immune system by long noncoding RNAs
Long noncoding RNAs (lncRNAs) are emerging as critical regulators of gene expression in
the immune system. Studies have shown that lncRNAs are expressed in a highly lineage …
the immune system. Studies have shown that lncRNAs are expressed in a highly lineage …
The RNA modification landscape in human disease
RNA modifications have been historically considered as fine-tuning chemo-structural
features of infrastructural RNAs, such as rRNAs, tRNAs, and snoRNAs. This view has …
features of infrastructural RNAs, such as rRNAs, tRNAs, and snoRNAs. This view has …
Dynamic landscape and regulation of RNA editing in mammals
Abstract Adenosine-to-inosine (A-to-I) RNA editing is a conserved post-transcriptional
mechanism mediated by ADAR enzymes that diversifies the transcriptome by altering …
mechanism mediated by ADAR enzymes that diversifies the transcriptome by altering …
Landscape of adenosine-to-inosine RNA recoding across human tissues
RNA editing by adenosine deaminases changes the information encoded in the mRNA from
its genomic blueprint. Editing of protein-coding sequences can introduce novel, functionally …
its genomic blueprint. Editing of protein-coding sequences can introduce novel, functionally …
ADAR1-mediated RNA editing of SCD1 drives drug resistance and self-renewal in gastric cancer
Targetable drivers governing 5-fluorouracil and cisplatin (5FU+ CDDP) resistance remain
elusive due to the paucity of physiologically and therapeutically relevant models. Here, we …
elusive due to the paucity of physiologically and therapeutically relevant models. Here, we …
Novel insight into the regulatory roles of diverse RNA modifications: Re-defining the bridge between transcription and translation
RNA modifications can be added or removed by a variety of enzymes that catalyse the
necessary reactions, and these modifications play roles in essential molecular mechanisms …
necessary reactions, and these modifications play roles in essential molecular mechanisms …