Periodontitis, a major inflammatory disease of the oral mucosa, is epidemiologically
associated with other chronic inflammation-driven disorders, including cardio-metabolic …

Atherosclerosis, a dominant and growing cause of death and disability worldwide, involves
inflammation from its inception to the emergence of complications. Targeting inflammatory …

Immune memory is a defining feature of the acquired immune system, but activation of the
innate immune system can also result in enhanced responsiveness to subsequent triggers …

Macrophages are a diverse set of cells present in all body compartments. This diversity is
imprinted by their ontogenetic origin (embryonal versus adult bone marrow–derived cells); …

Neutrophils are the first responders to infection and inflammation and are thus a critical
component of innate immune defense. Understanding the behavior of neutrophils as they …

The similarities and differences between trained immunity and other immune processes are
the subject of intense interrogation. Therefore, a consensus on the definition of trained …

Cellular heterogeneity and an immunosuppressive tumour microenvironment are
independent yet synergistic drivers of tumour progression and underlie therapeutic …

Metabolites produced by commensal gut microbes impact host health through their
recognition by the immune system and their influence on numerous metabolic pathways …

Sepsis arises from diverse and incompletely understood dysregulated host response
processes following infection that leads to life-threatening organ dysfunction. Here we …

The tuberculosis vaccine bacillus Calmette-Guérin (BCG) has heterologous beneficial
effects against non-related infections. The basis of these effects has been poorly explored in …