Vascular endothelial growth factor-A (VEGF-A) is a key mediator of angiogenesis, signalling
via the class IV tyrosine kinase receptor family of VEGF Receptors (VEGFRs). Although …

The correct development of blood vessels is crucial for all aspects of tissue growth and
physiology in vertebrates. The formation of an elaborate hierarchically branched network of …

Endothelial adherens junctions maintain vascular integrity. Arteries and veins differ in their
permeability but whether organization and strength of their adherens junctions vary has not …

Transforming growth factor-β (TGF-β) family members, which include TGF-βs, activins and
bone morphogenetic proteins, are pleiotropic cytokines that elicit cell type-specific effects in …

The development of the nervous and vascular systems constitutes primary events in the
evolution of the animal kingdom; the former provides electrical stimuli and coordination …

Filopodia,“the fingers that do the walking,” have been identified on endothelial cells at the tip
of sprouting vessels for half a century, but the key role of the tip cell in vessel branching has …

The Neuropilins (Nrps) are a family of essential cell surface receptors involved in multiple
fundamental cellular signaling cascades. Nrp family members have key functions in VEGF …

Vascular sprouting is a key process-driving development of the vascular system. In this
study, we show that neuropilin-2 (Nrp2), a transmembrane receptor for the lymphangiogenic …

Vascular endothelial growth factor-A (VEGF-A) has long been recognized as the key
regulator of vascular development and function in health and disease. VEGF is a secreted …

The neuropilins (Nrps) are multifunctional proteins involved in development, immunity and
cancer. Neuropilin-1 (Nrp1), or its homologue neuropilin-2 (Nrp2), are coreceptors that …